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Prevalence and Antifungal Susceptibility of Yeasts Obtained from the Oral Cavity of Elderly Individuals

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Abstract

Infections caused by Candida yeasts are common in elderly individuals. Seventy-five isolates of Candida spp. were obtained from saliva samples of 136 institutionalized elderly individuals resident in six retirement homes of Belo Horizonte, Brazil. Forty-seven isolates (62.66%) were identified as Candida albicans, 15 (20%) as C. tropicalis, 7 (9.33%) as C. glabrata, 4 (5.33) as C. parapsilosis, and 2 (2.67%) as C. guilliermondii. Among the 136 elderly individuals studied, 49 (36%) were male and 87 (64%) were female. Ages ranged from 60 to 90 years old. Sixty-three (46.3%) of the institutionalized individuals were denture wearers and, among them, 53 (84.1%) carried Candida yeasts in the oral cavity. Forty-four subjects presented lesions in the oral mucosa and among these, 36 (82%), had positive culture for Candida spp. The samples were tested for the in vitro susceptibility to amphotericin B, itraconazole, fluconazole and 5-flucytosin, and great variations were observed in the minimum inhibitory concentrations (MIC) of these drugs according to the species.

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References

  1. CL Kleinegger SR Lockhart K Vargas DR Soll (1996) ArticleTitleFrequency, intencity, species and strains of oral Candida vary as a function of host age J Clin Microbiol 34 2246–2255 Occurrence Handle8862593 Occurrence Handle1:STN:280:DyaK2s%2FhsF2mtA%3D%3D

    PubMed  CAS  Google Scholar 

  2. ANB Ellepola LP Samaranayake (1998) ArticleTitleAdhesion of oral C. albicans to human buccal epithelial cells following limited exposure to antifungal agents J Oral Pathol Med 27 325–332 Occurrence Handle9725570 Occurrence Handle1:CAS:528:DyaK1cXlslGqt7g%3D Occurrence Handle10.1111/j.1600-0714.1998.tb01964.x

    Article  PubMed  CAS  Google Scholar 

  3. AMG Darwazeh S Al-Refai S Al-Mojaiwel (2001) ArticleTitleIsolation of Candida species from the oral cavity and fingertips of complete denture wearers J Prosthet Den 86 420–423 Occurrence Handle1:STN:280:DC%2BD3Mnkt1Ohsw%3D%3D Occurrence Handle10.1067/mpr.2001.118020

    Article  CAS  Google Scholar 

  4. CL Kleinegger DC Stoeckel ZB Kurago (2001) ArticleTitleA comparison of salivary calcoprotectin levels in subject with and without oral candidiasis Oral Surg Oral Med Oral Pathol Oral Radiol Endod 92 62–67 Occurrence Handle11458247 Occurrence Handle1:STN:280:DC%2BD3Mvgs1Cqsg%3D%3D

    PubMed  CAS  Google Scholar 

  5. P Fotos J Hellstein (1992) ArticleTitleCandida and candidosis – Epidemiology, diagnosis, and therapeutic management Dent Clin North Am 36 857–878 Occurrence Handle1397438 Occurrence Handle1:STN:280:DyaK3s%2Fht1WnsA%3D%3D

    PubMed  CAS  Google Scholar 

  6. JL Maza N Elguezabal C Prado J Ellacuria I Soler J Pontón (2002) ArticleTitleCandida albicans adherence to resin composite restorative dental materials. Influence of the whole human salivates Oral Surg Oral Med Oral Pathol Oral Radiol Endod 94 589–592 Occurrence Handle12424453

    PubMed  Google Scholar 

  7. T Närhi THE Ainamo J Meurman (1993) ArticleTitleSalivary yeasts, and mucous oral in the elderly salivates J Dent Res 72 1009–1014 Occurrence Handle8496473

    PubMed  Google Scholar 

  8. SR Torres CB Peixoto DM Caldas EB Silva T Akiti M Nucci M Uzeda (2003) ArticleTitleRelationship between salivary flow rates and Candida counts in subjects with xerostomia Oral Surg Oral Med Oral Pathol Oral Radiol Endod 93 149–154 Occurrence Handle10.1067/moe.2002.119738

    Article  Google Scholar 

  9. C Haberland-Carrodeguas CM Allen FM Beck WJ Bueschiling SL Koletar P Sundstron (2002) ArticleTitlePrevalence of fluconazole-resistant strains of C. albicans in otherwise healthy outpatients J Oral Pathol Med 31 99–105 Occurrence Handle11896831 Occurrence Handle1:CAS:528:DC%2BD38XislCksrk%3D Occurrence Handle10.1034/j.1600-0714.2002.310207.x

    Article  PubMed  CAS  Google Scholar 

  10. DJ Sheehan CA Hitchcock CM Sibley (1999) ArticleTitleCurrent and emerging azole antifungal agents Clin Microbiol Res 12 40–79 Occurrence Handle1:CAS:528:DyaK1MXpvVOlsw%3D%3D

    CAS  Google Scholar 

  11. AND Cantón J Pemán O Viudes G Quindós M Gobernardo A Espinel-Ingroff (2003) ArticleTitleMinimum fungicidal concentrations of amphotericin B in bloodstream Candida species Diagn Microbiol Infect Dis 45 203–206 Occurrence Handle12663162 Occurrence Handle10.1016/S0732-8893(02)00525-4 Occurrence Handle1:CAS:528:DC%2BD3sXitlWrsrk%3D

    Article  PubMed  CAS  Google Scholar 

  12. O Espinel-Ingroff F Barchiesi KC Hazen V Martinez Suarez G Scalise (1998) ArticleTitleStandardization of antifungal susceptibility testing and clinical relevance Med Mycol 36 68–78 Occurrence Handle9988494 Occurrence Handle1:CAS:528:DyaK1MXhvVKqu78%3D

    PubMed  CAS  Google Scholar 

  13. AV Newton (1962) ArticleTitleDenture sore mouth: The possible etiology Br Dent J 112 357–360

    Google Scholar 

  14. Kurtzman CP, Fell J, eds. The Yeasts – The Taxonomic Study. Amsterdam: Elsevier Science Publisher, 1998

  15. NATIONAL COMMITEE FOR CLINICAL LABORATORY STANDARDS. Reference method for broth diluition antifungal susceptibility testing of yeasts. Standard Approved M27-A2-National Commitee for Clinical Laboratory Standards, Villanova, Pa., 2002

  16. S Fanello JP Bouchara N Jousset V Delbos AM Leflohic (2001) ArticleTitleNosocomial Candida albicans acquisition in the geriatric unit: Epidemiology and evidence goes person-to-person transmission J Hosp Infect 47 46–52 Occurrence Handle11161898 Occurrence Handle1:STN:280:DC%2BD3M7nvFamtg%3D%3D Occurrence Handle10.1053/jhin.2000.0849

    Article  PubMed  CAS  Google Scholar 

  17. K Yokoyama SK Biswas M Miyaji K Nishimura (2000) ArticleTitleIdentification and phylogenetic relationship of the most common pathogenic Candida species inferred from mitochondrial cytochrome b gene sequences J Clin Microbiol 38 4503–4510 Occurrence Handle11101587 Occurrence Handle1:CAS:528:DC%2BD3MXislClu78%3D

    PubMed  CAS  Google Scholar 

  18. SS Penha EG Birman FRX Silveira CR Paula (2000) ArticleTitleFrequency and enzymatic activity (proteinase and phospholipase) of Candida albicans from edentulous patients, with and without denture stomatitis Pesq Odontol Bras 14 119–122

    Google Scholar 

  19. P Saballs JM Toast-Rodrígues M Salvadó (2000) ArticleTitleLa candidemia en el syndrome of acquired inmunodeficiencia. Retrospective estudio de nueve casos Rev Iberoam Micol 17 2–5

    Google Scholar 

  20. P Sandven (2000) ArticleTitleEpidemiology of la candidemia Rev Iberoam Micol 17 73–81 Occurrence Handle15762797 Occurrence Handle1:STN:280:DC%2BD2M7jtlKktA%3D%3D

    PubMed  CAS  Google Scholar 

  21. A Stenderup (1990) ArticleTitleOral mycology Acta Odontol Scand 48 3–10 Occurrence Handle2181808 Occurrence Handle1:STN:280:DyaK3c3gvFGmsg%3D%3D

    PubMed  CAS  Google Scholar 

  22. B Collin CJ Clancy MH Nguyen (1999) ArticleTitleAntifungal resistance in non-albicans Candida species Drug Resist Updates 2 9–14 Occurrence Handle10.1054/drup.1998.0059

    Article  Google Scholar 

  23. DJ Sullivan TJ Westerneng KA Haynes DE Bennett DC Coleman (1995) ArticleTitleCandida dubliniensis sp. nov.: Phenotypic and molecular characterization of a novel species associated with oral candidosis in HIV-infected individuals Microbiology 141 1507–1521 Occurrence Handle7551019 Occurrence Handle1:CAS:528:DyaK2MXntFGgur0%3D Occurrence Handle10.1099/13500872-141-7-1507

    Article  PubMed  CAS  Google Scholar 

  24. CO Mosca MD Moragues S Brena AC Rosa J Ponton (2005) ArticleTitleIsolation of Candida dubliniensis in a teenager with denture stomatitis Med Oral Patol Oral Cir Bucal 10 25–28

    Google Scholar 

  25. JF Meis M Ruhnke BE Pauw ParticleDe FC Odds W Siegert PE Verweij (1999) ArticleTitleCandida dubliniensis candidemia in patients with chemotherapy-induced neutropenia and bone marrow transplantation Emerg Infect Dis 5 150–153 Occurrence Handle10081684 Occurrence Handle1:STN:280:DyaK1M7otFGhtw%3D%3D Occurrence Handle10.3201/eid0501.990119

    Article  PubMed  CAS  Google Scholar 

  26. I Espinoza R Rojas W Aranda J Gamonal (2003) ArticleTitlePrevalence of oral mucosal lesions in elderly people in Santiago, Chile J Oral Pathol Med 32 571–575 Occurrence Handle14632931 Occurrence Handle1:STN:280:DC%2BD3srlsVKltA%3D%3D Occurrence Handle10.1034/j.1600-0714.2003.00031.x

    Article  PubMed  CAS  Google Scholar 

  27. E Budtz-Jorgensen (1973) ArticleTitleCellular immunity in acquired candidiasis of the palate Scand Dent J Res Updates 81 372–382 Occurrence Handle1:STN:280:DyaE2c%2FlsVCqsQ%3D%3D

    CAS  Google Scholar 

  28. A Skoglund B Sunzel U Lerner (1994) ArticleTitleComparison of three test methods used goes diagnosis of candidiasis Scand J Dent Res 102 295–298 Occurrence Handle7529426 Occurrence Handle1:STN:280:DyaK2M7hs1yktQ%3D%3D

    PubMed  CAS  Google Scholar 

  29. JC Resende MA Resende (1999) ArticleTitleIn vitro susceptibility of clinical isolates of Candida spp. from hospitalized patients Mycoses 42 641–644 Occurrence Handle10680440 Occurrence Handle10.1046/j.1439-0507.1999.00522.x

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Microbiology, Institute of Biological Sciences, Federal University of Minas Gerais, Av. Antonio Carlos, 6627, Post office box 486, 31 270-901, Belo Horizonte, MG, Brazil

    Maria Aparecida de Resende, Lourimar Viana Nascimento Franco de Sousa, Rita Cássia Botelho Weikert de Oliveira, Cristiane Yumi Koga-Ito & Juliana Pereira Lyon

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  1. Maria Aparecida de Resende
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  2. Lourimar Viana Nascimento Franco de Sousa
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  3. Rita Cássia Botelho Weikert de Oliveira
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Correspondence to Maria Aparecida de Resende.

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de Resende, M.A., de Sousa, L.V.N.F., de Oliveira, R.C.B.W. et al. Prevalence and Antifungal Susceptibility of Yeasts Obtained from the Oral Cavity of Elderly Individuals. Mycopathologia 162, 39–44 (2006). https://doi.org/10.1007/s11046-006-0029-6

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  • DOI: https://doi.org/10.1007/s11046-006-0029-6

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