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Association study of leukocyte telomere length and genetic polymorphism within hTERT promoter with type 2 diabetes in Bangladeshi population

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Abstract

Telomeres are protective cap on the ends of DNA of non-coding tandem repeats of TTAGGG. Human telomerase reverse transcriptase (hTERT) is a catalytic subunit of telomerase that maintains the structure of telomeres. Type 2 diabetes (T2D) affects multi-organ and telomere length by altering telomerase activity. We aimed to evaluate the relative telomere length (RTL) and risk association of rs2853669 with T2D in Bangladeshi population. RTL was measured in 408 unrelated Bangladeshi (224 T2D and 184 healthy) using primers for target gene and reference gene albumin. Genotypic frequencies for rs2853669 were determined using TaqMan® probes. The mean level of age adjusted RTL (AARTL) varied significantly between the healthy and individuals with T2D for all the genotypes with respect to rs2853669. Moreover, healthy individuals had significantly higher AARTL than T2D. Similar findings were observed when study participants were stratified based on their gender. Association studies revealed that under codominant model of inheritance, TC genotype showed protective role against development of type 2 diabetes. This study suggests a possible role of telomere biology in T2DM, but their association needs to be evaluated further with a larger series and matched healthy controls.

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Acknowledgement

This research work was partly supported by the research grant from The World Academy of Sciences, (Ref No. 15-167 RG/BIO/AS_G-FR3240287016) awarded to Professor A.H.M. Nurun Nabi. Mr Atoll Goswami and Mr Nafiul Huda received studentships from The World Academy of Sciences.

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  1. Department of Biochemistry and Molecular Biology, University of Dhaka, Dhaka-1000, Bangladesh

    Atoll Goswami, Nafiul Huda, Tahirah Yasmin, Md. Ismail Hosen, A. K. M. Mahbub Hasan & A. H. M. Nurun Nabi

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  1. Atoll Goswami
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AHMNN conceived the idea. MIH designed and AG, NH, TY performed the experiments. AHMNN and AKMMH wrote the manuscript. All authors read and approved the manuscript.

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Correspondence to A. H. M. Nurun Nabi.

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Goswami, A., Huda, N., Yasmin, T. et al. Association study of leukocyte telomere length and genetic polymorphism within hTERT promoter with type 2 diabetes in Bangladeshi population. Mol Biol Rep 48, 285–295 (2021). https://doi.org/10.1007/s11033-020-06045-7

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