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Tumor necrosis factor (TNF) and TNFR1 polymorphisms are not risk factors for rheumatoid arthritis in a Mexican population

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Abstract

Tumor necrosis factor (TNF) plays an important role in the pathogenesis of rheumatoid arthritis (RA). Different genetic variants including the TNF −308G/A polymorphism are associated with RA susceptibility. However, these findings have not been replicated in all populations. The aim of this study was to determine whether the TNF −1031T/C (rs1799964), −376G/A (rs1800750), −308G/A (rs1800629) −238G/A (rs361525), and TNFR1 −609G/T polymorphisms are associated with RA susceptibility in a sample of Mexican patients. Our study included 499 patients with RA and 492 healthy controls. The genotypes of the TNF polymorphisms were obtained using TaqMan assay. The genotype and allele frequencies of the TNF −1031T/C, −376G/A, −308G/A, −238G/A, and TNFR1 −609G/T polymorphisms were similar among RA cases versus healthy controls, and no association with RA susceptibility was identified. Our results suggest that the TNF −1031T/C, −376G/A, −308G/A, −238G/A, and TNFR1 −609G/T polymorphisms are not associated with RA susceptibility in a sample of Mexican patients.

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Funding

This study was funded by a grant of the Consejo Nacional de Ciencia y Tecnología de México (CONACyT) (FOSISS; project no. 233107).

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Authors and Affiliations

  1. Research Unit on Endocrine and Metabolic Diseases, Hospital Juarez of México, Av. Instituto Politécnico Nacional 5160, Gustavo A. Madero, Magdalena de las Salinas, 07760, Mexico City, Mexico

    Daniel Cadena-Sandoval, Isidro Alemán-Ávila & Julián Ramírez-Bello

  2. Superior School of Medicine Postgraduate Program, National Polytechnic Institute, Mexico City, Mexico

    Daniel Cadena-Sandoval

  3. Rheumatology Department, Hospital Juarez of Mexico, Mexico City, Mexico

    Rosa Elda Barbosa-Cobos & Lizbeth Teresa Becerril-Mendoza

  4. Molecular Biology Laboratory, National Institute of Cardiology, Mexico City, Mexico

    José Manuel Fragoso

Authors
  1. Daniel Cadena-Sandoval
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  2. Isidro Alemán-Ávila
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  3. Rosa Elda Barbosa-Cobos
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  4. Lizbeth Teresa Becerril-Mendoza
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  5. José Manuel Fragoso
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  6. Julián Ramírez-Bello
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Correspondence to Julián Ramírez-Bello.

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Conflict of interest

No author has received research grants, except the corresponding author, who received the grant from the Consejo Nacional de Ciencia y Tecnología de México. The authors declare no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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Cadena-Sandoval, D., Alemán-Ávila, I., Barbosa-Cobos, R.E. et al. Tumor necrosis factor (TNF) and TNFR1 polymorphisms are not risk factors for rheumatoid arthritis in a Mexican population. Mol Biol Rep 45, 227–232 (2018). https://doi.org/10.1007/s11033-018-4155-2

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  • DOI: https://doi.org/10.1007/s11033-018-4155-2

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