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Association of a disintegrin and metalloprotease 33 (ADAM33) gene polymorphisms with the risk of COPD: an updated meta-analysis of 2,644 cases and 4,804 controls

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Abstract

A series of observational studies have been made to investigate the association of the ADAM33 gene polymorphisms with the risk of COPD, but their results were conflicting. Therefore, we performed an updated meta-analysis to quantitatively summarize the associations of ADAM33 gene polymorphisms with the risk of COPD. Thirteen case–control studies referring to nine SNPs were identified: V4 (rs2787094), T+1 (rs2280089), T2 (rs2280090), T1 (rs2280091), S2 (rs528557), S1 (rs3918396), Q−1 (rs612709), F+1 (rs511898) and ST+5 (rs597980). A dominant model (AA+Aa vs. aa), recessive model (AA vs. Aa+aa), additive model (AA vs. aa) and allelic model (A vs. a) were used to evaluate the association of ADAM33 polymorphism with the risk of COPD. The results indicated that significant associations were found for ADAM33 T1, T2, S1, Q−1, F+1 and ST+5 polymorphisms associated with the risk of COPD in different populations. However, no significant associations were found for V4, T+1 and S2 polymorphisms with the risk of COPD in all genetic models, even in the subgroup analysis by ethnicity. This meta-analysis provided evidence that the ADAM33 T1, T2, S1, Q−1, F+1 and ST+5 six locus polymorphisms association with the risk of COPD. Furthermore, T2, Q−1 and ST+5 indicated an association with the risk of COPD in the European populations, whereas T1, T2, S1, F+1 and Q−1 indicated an association with the risk of COPD in the Asian populations.

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Acknowledgements

This work was supported by a grant from College of Young Talents Foundation of Anhui Province (2010SQRL071ZD), the Natural Science Foundation of Anhui province (1208085QH170), the Specialized Research Fund for the Doctoral Program of Higher Education (20133420110001) and the National Natural Science Foundation of China (81371730, 81441090).

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The authors declare no conflict of interest.

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Authors and Affiliations

  1. Department of Emergency Medicine, The First Affiliated Hospital, Anhui Medical University, Hefei, 230022, Anhui, China

    Deng-Chuan Zhou

  2. Department of Occupational Health and Environmental Health, School of Public Health, Anhui Medical University, Hefei, 230032, Anhui, China

    Cheng-Fan Zhou, Tong Shen & Qi-Xing Zhu

  3. Institute of Dermatology, The First Affiliated Hospital, Anhui Medical University, Hefei, 230022, Anhui, China

    Cheng-Fan Zhou, Tong Shen & Qi-Xing Zhu

  4. School of Public Health and Social Work, Queensland University of Technology, Brisbane, QLD, 4059, Australia

    Sam Toloo & Shi-Lu Tong

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  1. Deng-Chuan Zhou
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  2. Cheng-Fan Zhou
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  4. Tong Shen
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Correspondence to Cheng-Fan Zhou or Qi-Xing Zhu.

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Deng-Chuan Zhou and Cheng-Fan Zhou have contributed equally to this work.

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Zhou, DC., Zhou, CF., Toloo, S. et al. Association of a disintegrin and metalloprotease 33 (ADAM33) gene polymorphisms with the risk of COPD: an updated meta-analysis of 2,644 cases and 4,804 controls. Mol Biol Rep 42, 409–422 (2015). https://doi.org/10.1007/s11033-014-3782-5

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  • DOI: https://doi.org/10.1007/s11033-014-3782-5

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