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RETRACTED ARTICLE: Relationships of LDLR genetic polymorphisms with cerebral infarction: a meta-analysis

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This article was retracted on 18 August 2015

Abstract

This meta-analysis was undertaken to identify the relationships between genetic polymorphisms in the LDLR gene and the risk of cerebral infarction. The Web of Science (1945–2013), the Cochrane Library Database (Issue 12, 2013), PubMed (1966–2013), EMBASE (1980–2013), CINAHL (1982–2013) and the Chinese Biomedical Database (CBM) (1982–2013) were searched for relevant articles without language restrictions. Meta-analysis was conducted using the STATA 12.0 software. Crude odds ratios (OR) with their corresponding 95 % confidence interval (CI) were calculated. Eight case–control studies with a total of 4,655 patients with cerebral infarction and 15,920 healthy control subjects were included in our meta-analysis. Five common polymorphisms in the LDLR gene were evaluated, including rs11669576 A > T, rs1433099 C > T, rs5925 C > T, rs688 C > T, rs1122608 T > G in the LDLR gene. The results of this meta-analysis revealed that cerebral infarction patients had a higher frequency of LDLR genetic polymorphisms than that of healthy controls (allele model: OR 1.17, 95 % CI 1.05–1.30, P = 0.004; dominant model: OR 1.18, 95 % CI 1.05–1.33, P = 0.007; homozygous model: OR 1.50, 95 % CI 1.03–2.16, P = 0.032; respectively), especially for the rs11669576 A > T, rs1433099 C > T and rs5925 C > T polymorphisms. Among different ethnic subgroups, the results demonstrated positive correlations between LDLR genetic polymorphisms and an increased risk of cerebral infarction among both Asians and Caucasians under the allele and dominant models (all P < 0.05). Our findings indicate that LDLR genetic polymorphisms may be strongly involved in the pathogenesis of cerebral infarction, especially the rs11669576 A > T, rs1433099 C > T, rs5925 C > T polymorphisms.

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Acknowledgments

We would like to acknowledge the reviewers for their helpful comments on this paper.

Conflict of interests

The authors declare no conflict of interest.

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Authors and Affiliations

  1. Department of Neurosurgery, Nanfang Hospital, Southern Medical University, Avenue North Road No. 1838, Guangzhou, 510515, People’s Republic of China

    Hai-Cheng Yan & Song-Tao Qi

  2. Department of Respiratory Medicine, Guangzhou Institute of Respiratory Diseases, Guangzhou, 510120, People’s Republic of China

    Wei Wang

  3. Department of Neurosurgery, Affiliated Hospital of Inner Mongolia Medical University, Hohhot, 010050, People’s Republic of China

    Chang-Wu Dou & Fu-Ming Tian

Authors
  1. Hai-Cheng Yan
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  2. Wei Wang
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  3. Chang-Wu Dou
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Corresponding author

Correspondence to Song-Tao Qi.

Additional information

Hai-Cheng Yan and Wei Wang are co-first authors.

The Publisher and Editor retract this article in accordance with the recommendations of the Committee on Publication Ethics (COPE). After a thorough investigation we have strong reason to believe that the peer review process was compromised.

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Yan, HC., Wang, W., Dou, CW. et al. RETRACTED ARTICLE: Relationships of LDLR genetic polymorphisms with cerebral infarction: a meta-analysis. Mol Biol Rep 41, 4425–4434 (2014). https://doi.org/10.1007/s11033-014-3313-4

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  • DOI: https://doi.org/10.1007/s11033-014-3313-4

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