Abstract
Several epidemiological studies have assessed the associations of interleukin (IL) gene polymorphisms with acute pancreatitis (AP) in different populations. However, the results were inconclusive. Therefore, we performed the present study to comprehensively evaluate the associations of IL gene polymorphisms and susceptibility to AP. Systematic searches of the PubMed, Web of Science, Embase, CNKI, CBMdisc and Google Scholar until February 27, 2013, as well as hand searching of the references of identified articles were performed. Data were extracted using standardized forms and odds ratios (ORs) with 95 % confidence intervals (CIs) were used to assess the strength of associations. All statistical analyses were performed using Stata 11.0. Ten studies were included in our final combined analysis, covering a total of 1,220 AP cases and 1,351 controls. The results showed evidence for significant association between IL-8 −251 T/A (rs4073) polymorphism and AP risk, suggesting that IL-8 −251 A allele was associated with an increased risk of AP (for A allele vs. T allele: OR = 1.36, 95 % CI 1.05–1.76, p = 0.02; for A/A vs. T/T: OR = 2.28, 95 % CI 1.08–4.81, p = 0.03; for A/A+T/A vs. T/T: OR = 1.40, 95 % CI 1.11–1.77, p = 0.005). However, there were no significant associations between IL-1β (IL-1β +3954 C/T (rs1143634) and IL-1β −511 C/T (rs16944)), IL-6 (IL-6 −174 G/C (rs1800795) and IL-6 −634 C/G (rs1800796)) and IL-10 (IL-10 −1082 A/G (rs1800896), IL-10 −819 C/T (rs1800871) and IL-10 −592 C/A (rs1800872)) gene polymorphisms and AP risk. In summary, the current study suggests that the IL-8 −251 T/A polymorphism is associated with an increased risk of AP. In addition, there were no significant associations between IL-1β, IL-6 and IL-10 gene polymorphisms and AP risk.
Similar content being viewed by others
References
Andersson R, Andersson B, Haraldsen P, Drewsen G, Eckerwall G (2004) Incidence, management and recurrence rate of acute pancreatitis. Scand J Gastroenterol 39:891–894
Goldacre MJ, Roberts SE (2004) Hospital admission for acute pancreatitis in an English population, 1963–98: database study of incidence and mortality. BMJ 328:1466–1469
Eland IA, Sturkenboom MJ, Wilson JH, Stricker BH (2000) Incidence and mortality of acute pancreatitis between 1985 and 1995. Scand J Gastroenterol 35:1110–1116
Gislason H, Horn A, Hoem D, Andrén-Sandberg A, Imsland AK, Søreide O, Viste A (2004) Acute pancreatitis in Bergen, Norway. A study on incidence, etiology and severity. Scand J Surg 93:29–33
Swaroop VS, Chari ST, Clain JE (2004) Severe acute pancreatitis. JAMA 291:2865–2868
Neoptolemos JP, Raraty M, Finch M, Sutton R (1998) Acute pancreatitis: the substantial human and financial costs. Gut 42:886–891
Lankisch PG, Blum T, Maisonneuve P, Lowenfels AB (2003) Severe acute pancreatitis: When to be concerned? Pancreatology 3:102–110
Mayer J, Rau B, Gansauge F, Beger HG (2000) Inflammatory mediators in human acute pancreatitis: clinical and pathophysiological implications. Gut 47:546–552
Kingsnorth A (1997) Role of cytokines and their inhibitors in acute pancreatitis. Gut 40:1–4
de Beaux AC, Goldie AS, Ross JA, Carter DC, Fearon KC (1996) Serum concentrations of inflammatory mediators related to organ failure in patients with acute pancreatitis. Br J Surg 83:349–353
Berney T, Gasche Y, Robert J, Jenny A, Mensi N, Grau G, Vermeulen B, Morel P (1999) Serum profiles of interleukin-6, interleukin-8, and interleukin-10 in patients with severe and mild acute pancreatitis. Pancreas 18:371–377
Chen CC, Wang SS, Lee FY, Chang FY, Lee SD (1999) Proinflammatory cytokines in early assessment of the prognosis of acute pancreatitis. Am J Gastroenterol 94:213–218
Hirota M, Nozawa F, Okabe A, Shibata M, Beppu T, Shimada S, Egami H, Yamaguchi Y, Ikei S, Okajima T, Okamoto K, Ogawa M (2000) Relationship between plasma cytokine concentration and multiple organ failure in patients with acute pancreatitis. Pancreas 21:141–146
Fishman D, Faulds G, Jeffery R, Mohamed-Ali V, Yudkin JS, Humphries S, Woo P (1998) The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis. J Clin Invest 102:1369–1376
Brull DJ, Montgomery HE, Sanders J, Dhamrait S, Luong L, Rumley A, Lowe GD, Humphries SE (2001) Interleukin-6 gene -174 g > c and -572 g > c promoter polymorphisms are strong predictors of plasma interleukin-6 levels after coronary artery bypass surgery. Arterioscler Thromb Vasc Biol 21:1458–1463
Nauck M, Winkelmann BR, Hoffmann MM, Böhm BO, Wieland H, März W (2002) The interleukin-6 G(-174)C promoter polymorphism in the LURIC cohort: no association with plasma interleukin-6, coronary artery disease, and myocardial infarction. J Mol Med (Berl) 80:507–513
Taguchi A, Ohmiya N, Shirai K, Mabuchi N, Itoh A, Hirooka Y, Niwa Y, Goto H (2005) Interleukin-8 promoter polymorphism increases the risk of atrophic gastritis and gastric cancer in Japan. Cancer Epidemiol Biomarkers Prev 14:2487–2493
Ohyauchi M, Imatani A, Yonechi M, Asano N, Miura A, Iijima K, Koike T, Sekine H, Ohara S, Shimosegawa T (2005) The polymorphism interleukin 8–251 A/T influences the susceptibility of Helicobacter pylori related gastric diseases in the Japanese population. Gut 54:330–335
Eskdale J, Gallagher G, Verweij CL, Keijsers V, Westendorp RG, Huizinga TW (1998) Interleukin 10 secretion in relation to human IL-10 locus haplotypes. Proc Natl Acad Sci USA 95:9465–9470
Kilpinen S, Huhtala H, Hurme M (2002) The combination of the interleukin-1alpha (IL-1alpha-889) genotype and the interleukin-10 (IL-10 ATA) haplotype is associated with increased interleukin-10 (IL-10) plasma levels in healthy individuals. Eur Cytokine Netw 13:66–71
Smithies AM, Sargen K, Demaine AG, Kingsnorth AN (2000) Investigation of the interleukin 1 gene cluster and its association with acute pancreatitis. Pancreas 20:234–240
Sargen K, Demaine AG, Kingsnorth AN (2000) Cytokine gene polymorphisms in acute pancreatitis. JOP 1:24–35
Powell JJ, Fearon KC, Siriwardena AK, Ross JA (2001) Evidence against a role for polymorphisms at tumor necrosis factor, interleukin-1 and interleukin-1 receptor antagonist gene loci in the regulation of disease severity in acute pancreatitis. Surgery 129:633–640
Zhang DL, Zheng HM, Yu BJ, Jiang ZW, Li JS (2005) Association of polymorphisms of IL and CD14 genes with acute severe pancreatitis and septic shock. World J Gastroenterol 11:4409–4413
Hofner P, Balog A, Gyulai Z, Farkas G, Rakonczay Z, Takács T, Mándi Y (2006) Polymorphism in the IL-8 gene, but not in the TLR4 gene, increases the severity of acute pancreatitis. Pancreatology 6:542–548
Chen XQ (2007) A study on the association between the interleukin-1β, interleukin-6 gene polymorphisms and the condition of patients with acute pancreatitis, Fujian Medical University (Master thesis), pp 1–49
Li Y, Huang HG, Chen XQ, Zhou YN (2007) The relationship of interleukin-8 gene-251A/T polymorphism and acute pancreatitis. J Fujian Med Univ 41:426–428
Chen WC, Nie JS (2008) Genetic polymorphism of MCP-1-2518, IL-8-251 and susceptibility to acute pancreatitis: a pilot study in population of Suzhou, China. World J Gastroenterol 14:5744–5748
Cao DQ, Xiao CZ (2010) Association between an interleukin-8 promoter polymorphism (−251A/T) and susceptibility to acute pancreatitis. World Chin J Digestol 18:3580–3583
Tang H, Liu CY, Wang XX, Li HY, Wen QS (2010) The relationship of interleukin-8 gene-251A/T polymorphism and acute pancreatitis. Prog Mod Biomed 10:3866–3868
Munafo MR, Flint J (2004) Meta-analysis of genetic association studies. Trends Genet 20:439–444
Higgins JP, Thompson SG, Deeks JJ, Altman DG (2003) Measuring inconsistency in meta-analyses. BMJ 327:557–560
Berkey CS, Hoaglin DC, Mosteller F, Colditz GA (1995) A random-effects regression model for meta-analysis. Stat Med 14:395–411
Mantel N, Haenszel W (1959) Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer 22:719–748
DerSimonian R, Laird N (1986) Meta-analysis in clinical trials. Control Clin Trials 7:177–188
Egger M, Davey Smith G, Schneider M, Minder C (1997) Bias in meta-analysis detected by a simple, graphical test. BMJ 315:629–634
International HapMap Project (2012) http://hapmap.ncbi.nlm.nih.gov. Accessed 8 Oct 2012
Acknowledgments
None.
Conflict of interest
None.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Yin, YW., Sun, QQ., Feng, JQ. et al. Influence of interleukin gene polymorphisms on development of acute pancreatitis: a systematic review and meta-analysis. Mol Biol Rep 40, 5931–5941 (2013). https://doi.org/10.1007/s11033-013-2700-6
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11033-013-2700-6