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A (S)-(+)-decursin derivative, (S)-(+)-3-(3,4-dihydroxy-phenyl)-acrylic acid 2,2-dimethyl-8-oxo-3,4-dihydro-2H,8H-pyrano[3,2-g]-chromen-3-yl-ester, attenuates the development of atopic dermatitis-like lesions in NC/Nga mice

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Abstract

(S)-(+)-decursin is a biological coumarin compound isolated from Angelica gigas Nakai. (S)-(+)-decursin and its analogue have a variety of pharmacological activities. In the present study, the anti-inflammatory effect of a (S)-(+)-decursin derivative, (S)-(+)-3-(3,4-dihydroxy-phenyl)-acrylic acid 2,2-dimethyl-8-oxo-3,4-dihydro-2H,8H-pyrano [3,2-g]-chromen-3-yl-ester (Compound 6, C6), on in vitro and in vivo atopic dermatitis was investigated. C6 suppressed the secretion of IL-6, IL-8, and monocyte chemotactic protein-1 increase by the house dust mite extract in the eosinophilic leukemia cell line and THP-1 cells. C6 inhibited the production of TARC, IL-6, and IL-8 increase by IFN-γ and TNF-α in the human keratinocyte cell line. In the in vivo experiment, NC/Nga mice were sensitized to 2,4-dinitrochlorobenzene, and then C6 or dexamethasone (Dex) were orally and dorsally administered for three weeks. C6 treatment reduced the skin severity score compared with that of the control group. C6 inhibited the thickening of the epidermis and inflammatory cell infiltration into the dermis by evaluating the histological examination. The serum immunoglobulin E (IgE) level decreased in the C6–treated group compared with that of the control group. The inhibitory effect of C6 on IgE concentration was similar to that of Dex. The levels of IL-4, IL-5, IL-13, and eotaxin increased after treatment with concanavalin A in mouse splenocytes. The cytokine levels of the C6-treated group were lower than those of the control group. Taken together, C6 may attenuate atopic dermatitis-like lesions through its anti-inflammatory effect, such as inhibition of IgE and inflammatory cytokines, and it may be valuable as a therapeutic drug for the treatment of atopic dermatitis.

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Abbreviations

AD:

Atopic dermatitis

C6:

(S)-(+)-3-(3,4-dihydroxy-phenyl)-acrylic acid 2,2-dimethyl-8-oxo-3,4-dihydro -2H,8H-pyrano[3,2-g]-chromen-3-yl-ester

FBS:

Fetal bovine serum

IgE:

Immunoglobulin E

MCP-1:

Monocyte chemotactic protein-1

DNCB:

2,4-dinitrochlorobenzene

PKC:

Protein kinase C

ERK:

Extracellular-signal-regulated kinase

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Acknowledgments

This work was supported by the RIC program of Ministry of Knowledge Economy (No.TBRC 05-06-02) in Daejeon University.

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Authors and Affiliations

  1. Department of Biomedical Laboratory Science, School of Medicine, Eulji University, Daejeon, 301-746, Republic of Korea

    In Sik Kim

  2. Department of Pathology, College of Oriental Medicine, Daejeon University, Daejeon, 300-716, Republic of Korea

    Dong-Hee Kim

  3. Department of Biology, Daejeon University, 96-3 Yongun-dong, Dong-gu, Daejeon, 300-716, Republic of Korea

    Chi-Young Yun

  4. Department of Clinical Laboratory Science, Wonkwang Health Science University, 501, Iksandaero, Iksan, 570-750, Republic of Korea

    Ji-Sook Lee

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  1. In Sik Kim
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  2. Dong-Hee Kim
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Correspondence to Ji-Sook Lee.

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Kim, I.S., Kim, DH., Yun, CY. et al. A (S)-(+)-decursin derivative, (S)-(+)-3-(3,4-dihydroxy-phenyl)-acrylic acid 2,2-dimethyl-8-oxo-3,4-dihydro-2H,8H-pyrano[3,2-g]-chromen-3-yl-ester, attenuates the development of atopic dermatitis-like lesions in NC/Nga mice. Mol Biol Rep 40, 2541–2548 (2013). https://doi.org/10.1007/s11033-012-2339-8

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  • DOI: https://doi.org/10.1007/s11033-012-2339-8

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