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Interleukin-6 gene −174G>C and −636G>C promoter polymorphisms and prostate cancer risk

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Abstract

Prostate cancer (PCa) is one of the most commonly diagnosed internal malignancies affecting men. Due to the important roles of IL-6 in different physiological and pathophysiological processes, IL-6 polymorphisms may modulate PCa risk. IL-6 −174 G>C (rs 1800795, also designated −236 G>C) and −636 G>C (rs 1800796, also designated −572 G>C) promoter polymorphisms have been implicated in PCa susceptibility, albeit still controversial. A literature search using PubMed and Highwire databases was conducted, resulting in eight case–control studies concerning the IL-6 −174 G>C polymorphism (11,613 PCa cases and 13,992 controls) and four case–control publications regarding the IL-6 −636 G>C polymorphism (1,941 PCa cases and 3,357 controls). In order to derive a more precise estimation, a meta-analysis based upon these selected case–control studies was performed. There was no significant association between IL-6 −174 G>C polymorphism and PCa increased risk. Nevertheless, the presence of allele C and the CC genotype were statistically significantly associated with decreased PCa risk in the overall analysis for IL-6 −636 G>C polymorphism. Additional studies in larger samples and analyses of functional repercussions of these SNPs in prostate tumor cells are necessary to validate these findings.

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Authors and Affiliations

  1. Centre of Genomics and Biotechnology, Institute for Biotechnology and Bioengineering, University of Trás-os-Montes and Alto Douro (CGB-UTAD/IBB), Quinta dos Prados, P.O. Box 1013, 5001-801, Vila Real, Portugal

    J. F. Magalhães, C. M. Albuquerque, C. S. Baptista, Henrique Guedes-Pinto & E. Bastos

  2. Research Center in Sports Sciences, Health Sciences and Human Development (CIDESD), University of Trás-os-Montes and Alto Douro, P.O. Box 1013, 5001-801, Vila Real, Portugal

    A. J. Cortinhas & J. C. Leitão

  3. Multidisciplinary Unit for Biomedical Research, Institute of Biomedical Sciences Abel Salazar, University of Porto (ICBAS-UMIB-UP), Porto, Portugal

    C. S. Baptista

  4. Molecular Oncology Group—CI, Portuguese Institute of Oncology, Porto Centre, Rua Dr. António Bernardino Almeida, 4200-072, Porto, Portugal

    R. Ribeiro

  5. Department of Veterinary Sciences, CECAV—Agricultural and Veterinary Sciences School, University of Trás-os-Montes and Alto Douro, Quinta dos Prados, P.O. Box 1013, 5001-801, Vila Real, Portugal

    A. Martins-Bessa

  6. Department of Veterinary Sciences, School of Agriculture and Veterinary Sciences, University of Trás-os-Montes and Alto Douro (UTAD), Vila Real, Portugal

    Carlos Viegas, João Machado & Maria A. Pires

  7. 3Bs, University of Minho, Guimarães, Portugal

    Carlos Viegas

  8. Multidisciplinary Unit for Biomedical Research (UMIB), University of Porto, Porto, Portugal

    Augusto Matos

  9. Department of Veterinary Clinics, Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto (ICBAS-UP), Porto, Portugal

    Augusto Matos

  10. Department of Veterinary Sciences, CECAV—Veterinary and Animal Research Centre, University of Trás-os-Montes and Alto Douro (UTAD), Vila Real, Portugal

    Maria A. Pires

Authors
  1. J. F. Magalhães
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  2. A. J. Cortinhas
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  3. C. M. Albuquerque
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  4. C. S. Baptista
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  5. R. Ribeiro
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  6. Carlos Viegas
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  7. Augusto Matos
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  8. João Machado
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  9. Maria A. Pires
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  10. Henrique Guedes-Pinto
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  11. A. Martins-Bessa
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  12. J. C. Leitão
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  13. E. Bastos
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Corresponding author

Correspondence to E. Bastos.

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Magalhães, J.F., Cortinhas, A.J., Albuquerque, C.M. et al. Interleukin-6 gene −174G>C and −636G>C promoter polymorphisms and prostate cancer risk. Mol Biol Rep 40, 449–455 (2013). https://doi.org/10.1007/s11033-012-2079-9

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  • DOI: https://doi.org/10.1007/s11033-012-2079-9

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