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APE1 Asp148Glu gene polymorphism and bladder cancer risk: a meta-analysis

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Abstract

Published data regarding the association between the apurinic/apyrimidinic endonuclease 1 (APE1) Asp148Glu polymorphism and bladder cancer risk showed inconclusive results. This meta-analysis of literatures was performed to draw a more precise estimation of the relationship. We systematically searched PubMed, Embase, Elsevier and Springer for relevant articles with a time limit of Jan. 2012. The strength of association between APE1 Asp148Glu polymorphism and bladder cancer risk was assessed by odds ratio (OR) with the corresponding 95 % confidence interval (95 % CI) using the software STATA(version10.0).A total of 11 case–control studies including 4,292 cases and 4,761 controls based on the search criteria were included for analysis. Overall, for GG versus TT, the pooled OR was 0.952 (95 % CI = 0.778–1.166), for the the G allele carriers (TG + GG) versus homozygote TT, the pooled OR was 0.984 (95 % CI = 0.897–1.078). In the stratified analysis by ethnicity, significantly risks were not found among Asians for GG versus TT (OR = 0.469; 95 % CI = 0.162–1.357) nor (TG + GG) versus TT (OR = 0.921, 95 % CI = 0.742–1.143). Similarly, for non-Asians, significantly risks were also not found for GG versus TT (OR = 0.992; 95 % CI = 0.861–1.144) nor (TG + GG) versus TT (OR = 1.010, 95 % CI = 0.897–1.137). This meta-analysis suggested that the APE1 T1349G (Asp148Glu) polymorphism was not associated with bladder cancer risk among Asians nor non-Asians.

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Authors and Affiliations

  1. Department of Oncology, Changhai Hospital, Second Military Medical University, Changhai Hospital, 168 Changhai Road, Shanghai, People’s Republic of China

    Chuan Liu & Yajie Wang

  2. Yueyang Second People’s Hospital, The First Affiliated Hospital of University of South China, Hengyang, People’s Republic of China

    Qinghua Yin

  3. Yueyang Second People’s Hospital, Yueyang, People’s Republic of China

    Lian Li

  4. Department of Medical Oncology, The First Affiliated Hospital of University of South China, 69 Chuanshan Road, Hengyang, People’s Republic of China, 421001

    Ying-zhi Zhuang & Xuyu Zu

Authors
  1. Chuan Liu
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  2. Qinghua Yin
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  3. Lian Li
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  4. Ying-zhi Zhuang
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  5. Xuyu Zu
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  6. Yajie Wang
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Correspondence to Ying-zhi Zhuang or Yajie Wang.

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Chuan Liu and Qinghua Yin contributed equally to the study.

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Liu, C., Yin, Q., Li, L. et al. APE1 Asp148Glu gene polymorphism and bladder cancer risk: a meta-analysis. Mol Biol Rep 40, 171–176 (2013). https://doi.org/10.1007/s11033-012-2046-5

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  • DOI: https://doi.org/10.1007/s11033-012-2046-5

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