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Associations of polymorphisms in the β2-adrenergic receptor gene with essential hypertension in Han Chinese population

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Abstract

The β2-adrenergic receptor (β2-AR) gene has been implicated in the pathogenesis of hypertension. However, the results have been conflicting. In this study, we performed a meta-analysis to assess the associations of 46A/G and 79C/G polymorphisms in β2-AR gene with hypertension risk in Han Chinese population. Published literature from PubMed, ISI Web of Science, Embase databases, CNKI, CBM and Wanfang Data were retrieved. Pooled odds ratio (OR) with 95 % confidence interval (CI) was calculated using fixed- or random-effects model. Eleven studies (2,058 cases and 1,459 controls) for 46A/G polymorphism and eight studies (2,219 cases and 1,495 controls) for 79C/G polymorphism were identified. The results suggested that 46A/G polymorphism G allele might increase the risk of hypertension (GG vs. AA: OR = 1.47, 95 % CI 1.20–1.82). However, no significant association was observed for 79C/G polymorphism (GG vs. CC: OR = 1.05, 95 % CI 0.61–1.79). The results indicated that 46A/G polymorphism in the β2-AR gene was associated with hypertension susceptibility in Han Chinese population.

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The authors declare no conflict of interest.

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Authors and Affiliations

  1. Department of Cardiology, The First Affiliated Hospital of South China University, Hengyang, 421001, China

    Zhenwang Tang

  2. Department of Geriatrics Cardiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, China

    Xingsheng Li

  3. Department of Pharmacology, Hunan University of Chinese Medicine, Changsha, 410007, China

    Duanfang Liao

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  1. Zhenwang Tang
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  2. Xingsheng Li
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  3. Duanfang Liao
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Correspondence to Zhenwang Tang.

Additional information

Zhenwang Tang and Xingsheng Li contributed equally to this work.

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Tang, Z., Li, X. & Liao, D. Associations of polymorphisms in the β2-adrenergic receptor gene with essential hypertension in Han Chinese population. Mol Biol Rep 39, 9339–9345 (2012). https://doi.org/10.1007/s11033-012-1750-5

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