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No significant association between Fc receptor-like 3 gene polymorphisms and human leukocyte antigen-B27 positive ankylosing spondylitis in Han Chinese population

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Abstract

Ankylosing spondylitis (AS) is a rhematoid arthritis, which is a common autoimmune disease with a complex genetic etiology. Although HLA-B27 has been identified to be associated with AS, a number of other genes may also be involved in the disease. Fc receptor-like 3 (FCRL3) gene has been shown to be associated with rheumatoid arthritis in Japanese population. Here we aim to explore the association FCRL3 gene and susceptibility to human leukocyte antigen (HLA)-B27-positive AS in Han Chinese population. Among 169 AS patients, the frequencies of C and T (rs7522061) in FCRL3 gene were 38.7 and 61.3%, respectively; in 184 controls (HLA-B27-positive), the frequencies of C and T were 38.6 and 61.4%, respectively. The frequencies of alleles and genotype are not of statistically significant difference in two groups (χ2 = 0.000, P = 0.983; χ2 = 0.099, P = 0.952, respectively),but the distribution of HLA-B27 subtypes are statistically significant difference between cases and controls (χ2 = 8.214, P = 0.042). Our data reveal that the FCRL3 gene does not appear associated with susceptibility to HLA-B27-positive AS in Han Chinese population.

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References

  1. Choi CB, Kim TJ, Park HJ et al (2008) Safety and clinical responses in ankylosing spondylitis after three months of etanercept therapy. J Korean Med Sci 23:852–856

    Article  CAS  PubMed  Google Scholar 

  2. Brown MA (2008) Breakthroughs in genetic studies of ankylosing spondylitis. Rheumatology (Oxford) 47:132–137

    Article  CAS  Google Scholar 

  3. Brown MA, Kennedy LG, MacGregor AJ et al (1997) Susceptibility to ankylosing spondylitis in twins: the role of genes, HLA, and the environment. Arthritis Rheum 40:1823–1828

    Article  CAS  PubMed  Google Scholar 

  4. Brown MA, Laval SH, Brophy S, Calin A (2000) Recurrence risk modelling of the genetic susceptibility to ankylosing spondylitis. Ann Rheum Dis 59:883–886

    Article  CAS  PubMed  Google Scholar 

  5. Chistiakov DA, Chistiakov AP (2007) Is FCRL3 a new general autoimmunity gene? Hum Immunol 68:375–383

    Article  CAS  PubMed  Google Scholar 

  6. Kochi Y, Yamada R, Suzuki A et al (2005) A functional variant in FCRL3, encoding Fc receptor-like 3, is associated with rheumatoid arthritis and several autoimmunities. Nat Genet 37:478–485

    Article  CAS  PubMed  Google Scholar 

  7. van der Linden S, Valkenburg HA, Cats A (1984) Evaluation of diagnostic criteria for ankylosing spondylitis. A proposal for modification of the New York criteria. Arthritis Rheum 27:361–368

    Article  PubMed  Google Scholar 

  8. Garcia-Fernandez S, Gonzalez S, Mina Blanco A et al (2001) New insights regarding HLA-B27 diversity in the Asian population. Tissue Antigens 58:259–262

    Article  CAS  PubMed  Google Scholar 

  9. Shi YY, He L (2005) SHEsis, a powerful software platform for analyses of linkage disequilibrium, haplotype construction, and genetic association at polymorphism loci. Cell Res 15(2):97–98

    Article  CAS  PubMed  Google Scholar 

  10. Masir N, Jones M, Pozzobon M et al (2004) Expression pattern of FCRL (FREB, FcRX) in normal and neoplastic human B cells. Br J Haematol 127:335–343

    Article  CAS  PubMed  Google Scholar 

  11. Choi CB, Kang CP, Seong SS, Bae SC, Kang C (2006) The -169C/T polymorphism in FCRL3 is not associated with susceptibility to rheumatoid arthritis or systemic lupus erythematosus in a case-control study of Koreans. Arthritis Rheum 54:3838–3841

    Article  CAS  PubMed  Google Scholar 

  12. Hu X, Chang M, Saiki RK et al (2006) The functional -169T→C single-nucleotide polymorphism in FCRL3 is not associated with rheumatoid arthritis in white North Americans. Arthritis Rheum 54:1022–1025

    Article  PubMed  Google Scholar 

  13. Martinez A, Sanchez E, Valdivia A et al (2006) Epistatic interaction between FCRL3 and NFkappaB1 genes in Spanish patients with rheumatoid arthritis. Ann Rheum Dis 65:1188–1191

    Article  CAS  PubMed  Google Scholar 

  14. Eyre S, Bowes J, Potter C, Worthington J, Barton A (2006) Association of the FCRL3 gene with rheumatoid arthritis: a further example of population specificity? Arthritis Res Ther 8:R117

    Article  PubMed  Google Scholar 

  15. Burton PR, Clayton DG, Cardon LR et al (2007) Association scan of 14, 500 nonsynonymous SNPs in four diseases identifies autoimmunity variants. Nat Genet 39(11):1329–1337

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgments

This work was supported by grants from the National Natural Science Foundation of China (30771849), Anhui Medical University Dr. Priming Fund (01XJ2006001), Natural Science Foundation of Anhui Province (090413133) and Anhui Science and Technology Department annual research program (08020303070). We thank all volunteers for their enthusiastic participation in this study.

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No conflict of interest is declared.

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Authors and Affiliations

  1. Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, 230032, Hefei, Anhui, China

    Guo Xia, Faming Pan, Fangfang Liao, Xiaowu Tang, Rui Ge, Yang Mei & Heping Pan

  2. Department of Rheumatology, First Affiliated Hospital, Anhui Medical University, 230032, Hefei, China

    Shengqian Xu & Jianhua Xu

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  1. Guo Xia
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  2. Faming Pan
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  3. Fangfang Liao
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  4. Xiaowu Tang
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  5. Rui Ge
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  6. Yang Mei
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  7. Heping Pan
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  8. Shengqian Xu
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  9. Jianhua Xu
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Correspondence to Faming Pan.

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Xia, G., Pan, F., Liao, F. et al. No significant association between Fc receptor-like 3 gene polymorphisms and human leukocyte antigen-B27 positive ankylosing spondylitis in Han Chinese population. Mol Biol Rep 37, 297–300 (2010). https://doi.org/10.1007/s11033-009-9690-4

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  • DOI: https://doi.org/10.1007/s11033-009-9690-4

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