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Asp327Asn polymorphism of sex hormone-binding globulin gene is associated with systemic lupus erythematosus incidence

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Abstract

Endogenous sex hormones have been observed to have a role in systemic lupus erythematosus (SLE) predisposition. Sex hormone-binding globulin (SHBG) regulates the bioavailability of sex hormones to target tissues. Therefore, we examined the distribution of the SHBG functional polymorphism Asp327Asn (rs6259) in SLE patients (n = 150) and controls (n = 150) in a Polish population. We found a contribution of the SHBG327Asn variant to the development of SLE. Women with the Asp/Asn and Asn/Asn genotypes displayed a 2.630-fold increased risk of SLE (95% CI = 1.561–4.433, P = 0.0003). SHBG has a much higher affinity for testosterone than estradiol, and the SHBG327Asn variant displays a reduction of estradiol clearance. Therefore we suggest that the opposing effects of estrogens and testosterone on the immune system and imbalance in the levels of these hormones in SLE patients can be enhanced by the SHBG327Asn protein variant.

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Acknowledgments

Supported by grant No 502-01-01124182-07474 from Poznań University of Medical Sciences.

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Authors and Affiliations

  1. Department of Biochemistry and Molecular Biology, Poznań University of Medical Sciences, 6 Święcickiego St., 60-781, Poznan, Poland

    Piotr Piotrowski, Robert Gasik, Margarita Lianeri & Paweł P. Jagodziński

  2. Department of Rheumatology and Clinical Immunology, Poznan University of Medical Sciences, Poznan, Poland

    Dorota Cieślak & Paweł Hrycaj

  3. Institute of Rheumatology, Warsaw, Poland

    Mariusz Wudarski & Jan K. Łącki

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  1. Piotr Piotrowski
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  2. Robert Gasik
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  8. Paweł P. Jagodziński
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Correspondence to Paweł P. Jagodziński.

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Piotrowski, P., Gasik, R., Lianeri, M. et al. Asp327Asn polymorphism of sex hormone-binding globulin gene is associated with systemic lupus erythematosus incidence. Mol Biol Rep 37, 235–239 (2010). https://doi.org/10.1007/s11033-009-9639-7

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  • DOI: https://doi.org/10.1007/s11033-009-9639-7

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