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Synthesis of novel fused quinazolinone derivatives

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Abstract

A four-step synthetic route was developed for the synthesis of novel fused quinazolinones, quinazolino[3,4-a]quinazolinones, and isoinodolo[2,1-a]quinazolino[1,2-c]quinazolineones. Reaction of isatoic anhydride and different amines gave various 2-aminobenzamides. Then, reaction of 2-aminobenzamides with 2-nitrobenzaldehyde followed by the reduction of nitro group afforded 2-(2-aminophenyl)-3-aryl-2,3-dihydroquinazolin-4(1H)-one derivatives. Finally, reaction of the latter compounds with aromatic aldehydes or 2-formylbenzoic acid led to the formation of the corresponding products.

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Acknowledgments

This research was supported by the grants from the research council of the Tehran University of Medical Sciences and Iran National Science Foundation (INSF).

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Authors and Affiliations

  1. Drug Design and Development Research Center, Tehran University of Medical Sciences, Tehran, Iran

    Mohammad Mahdavi

  2. School of Chemistry, College of Science, University of Tehran, P.O. Box 14155-6455, Tehran, Iran

    Vahid Lotfi & Ebrahim Kianmehr

  3. Medicinal Plants Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

    Mina Saeedi

  4. Persian Medicine and Pharmacy Research Center, Tehran University of Medical Sciences, Tehran, Iran

    Mina Saeedi

  5. Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran

    Abbas Shafiee

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  1. Mohammad Mahdavi
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  2. Vahid Lotfi
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  3. Mina Saeedi
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  4. Ebrahim Kianmehr
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  5. Abbas Shafiee
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Correspondence to Abbas Shafiee.

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Mahdavi, M., Lotfi, V., Saeedi, M. et al. Synthesis of novel fused quinazolinone derivatives. Mol Divers 20, 677–685 (2016). https://doi.org/10.1007/s11030-016-9675-x

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