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A simple and efficient synthesis of fused morpholine pyrrolidines/piperdines with potential insecticidal activities

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Abstract

A simple and efficient synthesis of fused morpholine pyrrolidine/piperdine core structures was accomplished via a Petasis-borono Mannich reaction of cyclic amino alcohols, glyoxal and arylboronic acids with moderate to good yields. The bioassay data showed that the synthesized compounds displayed selective insecticidal activities against armyworm and root-knot nematode.

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Acknowledgments

Financial support for this work from National Basic Research Program of China (973 Program) (Grant 2010CB126101) and National Natural Science Foundation of China (Grant 20972052) are gratefully acknowledged.

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Authors and Affiliations

  1. Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai, 200237, People’s Republic of China

    Jiayi Wang, Beiling Xu, Shanyu Si, Hui Li & Gonghua Song

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  1. Jiayi Wang
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  2. Beiling Xu
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  3. Shanyu Si
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  4. Hui Li
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  5. Gonghua Song
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Correspondence to Gonghua Song.

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Wang, J., Xu, B., Si, S. et al. A simple and efficient synthesis of fused morpholine pyrrolidines/piperdines with potential insecticidal activities. Mol Divers 18, 887–893 (2014). https://doi.org/10.1007/s11030-014-9531-9

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  • DOI: https://doi.org/10.1007/s11030-014-9531-9

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