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One-pot synthesis of 1,2,3-triazole linked dihydropyrimidinones via Huisgen 1,3-dipolar/Biginelli cycloaddition

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Abstract

The combination of the Biginelli reaction with click chemistry has been used for the one-pot synthesis of 1,2,3-triazole linked dihydropyrimidinones from azides, aromatic aldehydes containing a propargyl ether group, urea, and 1,3-dicarbonyl compounds using Cu(OAc)2/sodium ascorbate as catalyst in acetic acid under mild reaction conditions.

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Correspondence to Minoo Dabiri.

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Salehi, P., Dabiri, M., Koohshari, M. et al. One-pot synthesis of 1,2,3-triazole linked dihydropyrimidinones via Huisgen 1,3-dipolar/Biginelli cycloaddition. Mol Divers 15, 833–837 (2011). https://doi.org/10.1007/s11030-011-9313-6

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