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No association between plasma adiponectin levels and central auditory function in adults

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Abstract

Adiponectin might play a protective role in cardiometabolic and peripheral auditory disorders, but its role on central auditory function was still unclear. The aim of this study was to examine whether there is an association between plasma adiponectin levels and central auditory function in adults. We recruited 297 adults, with normal or symmetrical sensorineural hearing loss and normal cognitive functions. Multivariate linear regression was performed to assess the association between plasma adiponectin concentrations and pitch pattern sequence (PPS) score, which was one of central auditory tests. The results showed that there were 224 (75.4 %) women and 73 (24.6 %) men in this study. The mean age was 58.1 ± 8.4 years, the mean waist circumference (WC) was 81.1 ± 8.3 cm, and the mean body mass index (BMI) was 24.0 ± 3.0 kg/m2. The mean PPS score was 71.5 ± 14.1 %, and plasma adiponectin concentration was 12.7 ± 5.5 g/mL. After adjusting for age, gender, WC, coronary artery disease, hypertension, diabetes mellitus, chronic kidney disease, smoking and drinking, plasma adiponectin concentrations (coefficient ± standard error, β ± SE = −0.09 ± 0.16, p = 0.563) were found to have no significant associations with PPS score. When WC was excluded from these variables in the multivariate linear regression model, plasma adiponectin concentrations (β ± SE = −0.03 ± 0.15, p = 0.855) were still not significantly associated with PPS score. In conclusion, plasma adiponectin levels were not significantly associated with PPS score, which was one of central auditory function tests. More studies should be conducted for the underlying mechanisms of obesity-related central auditory dysfunction.

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Funding

This project was supported by grant DTCRD-98-03 to JHH and NSC-2314-002-050MY3 to WSY.

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The authors have no conflicts of interest to declare.

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Authors and Affiliations

  1. Department of Otolaryngology, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Chiayi, Taiwan

    Juen-Haur Hwang

  2. School of Medicine, Tzu Chi University, Hualien, Taiwan

    Juen-Haur Hwang

  3. Department of Internal Medicine, National Taiwan University Hospital, No. 7, Chung-Shan S. Road, Taipei, 100, Taiwan

    Fen-Yu Tseng & Wei-Shiung Yang

  4. Department of Otolaryngology, National Taiwan University Hospital, No. 7, Chung-Shan S. Road, Taipei, 100, Taiwan

    Tien-Chen Liu

  5. Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan

    Wei-Shiung Yang

Authors
  1. Juen-Haur Hwang
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  2. Fen-Yu Tseng
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  3. Tien-Chen Liu
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  4. Wei-Shiung Yang
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Correspondence to Tien-Chen Liu or Wei-Shiung Yang.

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Hwang, JH., Tseng, FY., Liu, TC. et al. No association between plasma adiponectin levels and central auditory function in adults. Metab Brain Dis 30, 191–196 (2015). https://doi.org/10.1007/s11011-014-9597-1

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  • DOI: https://doi.org/10.1007/s11011-014-9597-1

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