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Neuroprotective effects of Pouteria ramiflora (Mart.) Radlk (Sapotaceae) extract on the brains of rats with streptozotocin-induced diabetes

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Abstract

Diabetes mellitus is a chronic disease involving persistent hyperglycemia, which causes an imbalance between reactive oxygen species and antioxidant enzymes and results in damage to various tissues, including the brain. Many societies have traditionally employed medicinal plants to control the hyperglycemia. Pouteria ramiflora, a species occurring in the savanna biome of the Cerrado (Brazil) has been studied because of its possible ability to inhibit carbohydrate digestion. Rats with streptozotocin-induced diabetes treated with an alcoholic extract of Pouteria ramiflora show an improved glycemic level, increased glutathione peroxidase activity, decreased superoxide dismutase activity, and reduced lipid peroxidation and antioxidant status. The extract also restored myosin-Va expression and the nuclear diameters of pyramidal neurons of the CA3 subregion and that of the polymorphic cells of the hilus. We conclude that Pouteria ramiflora extract exerts a neuroprotective effect against oxidative damage and myosin-Va expression and is able to prevent hippocampal neuronal loss in the CA3 and hilus subfields of diabetic rats. However, future studies are needed to understand the mechanism of action of Pouteria ramiflora extract in acute and chronic diabetes.

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Acknowledgments

The authors thank Fernanda Vieira Alves for technical support and the Laboratory of Clinical Analysis of the School of Veterinary Medicine, Federal University of Uberlândia, especially Antônio Vicente Mundim and Felipe Cesar Gonçalves, for help in processing the biochemical data. This work was supported by grants from FAPEMIG to FSE, by a CAPES fellowship to LKC, RJOS and NMG, and a FAPEMIG fellowship to FBF.

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Author notes

  1. Vanessa Neves de Oliveira

    Present address: Federal University of Juiz de Fora, Campus Juiz de Fora, 36036-900, Juiz de Fora, MG, Brazil

  2. Luciana Karen Calábria

    Present address: Federal University of Juiz de Fora, Campus Governador Valadares, 35010-177, Governador Valadares, MG, Brazil

Authors and Affiliations

  1. Institute of Genetics and Biochemistry, Federal University of Uberlândia, Campus Umuarama, Av. Pará, s/n, 38400-902, Uberlândia, MG, Brazil

    Alice Vieira da Costa, Luciana Karen Calábria, Fabiana Barcelos Furtado, Neire Moura de Gouveia, Renato José da Silva Oliveira, Vanessa Neves de Oliveira, Marcelo Emilio Beletti & Foued Salmen Espindola

  2. Institute of Biomedical Sciences, Federal University of Uberlândia, Campus Umuarama, Av. Pará, s/n, 38400-902, Uberlândia, MG, Brazil

    Marcelo Emilio Beletti

  3. Universidade Federal de Uberlândia, Instituto de Genética e Bioquímica, Laboratório de Bioquímica e Biologia Molecular, Campus Umuarama, Bloco 2E, sala 235, 38400-902, Uberlândia, MG, Brazil

    Foued Salmen Espindola

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  1. Alice Vieira da Costa
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Correspondence to Foued Salmen Espindola.

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da Costa, A.V., Calábria, L.K., Furtado, F.B. et al. Neuroprotective effects of Pouteria ramiflora (Mart.) Radlk (Sapotaceae) extract on the brains of rats with streptozotocin-induced diabetes. Metab Brain Dis 28, 411–419 (2013). https://doi.org/10.1007/s11011-013-9390-6

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