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CREB1 regulates glucose transport of glioma cell line U87 by targeting GLUT1

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Abstract

Glioma is stemmed from the glial cells in the brain, which is accounted for about 45% of all intracranial tumors. The characteristic of glioma is invasive growth, as well as there is no obvious boundary between normal brain tissue and glioma tissue, so it is difficult to resect completely with worst prognosis. The metabolism of glioma is following the Warburg effect. Previous researches have shown that GLUT1, as a glucose transporter carrier, affected the Warburg effect, but the molecular mechanism is not very clear. CREB1 (cAMP responsive element-binding protein1) is involved in various biological processes, and relevant studies confirmed that CREB1 protein regulated the expression of GLUT1, thus mediating glucose transport in cells. Our experiments mainly reveal that the CREB1 could affect glucose transport in glioma cells by regulating the expression of GLUT1, which controlled the metabolism of glioma and affected the progression of glioma.

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Acknowledgements

This research was supported by the Chinese National Natural Science Foundation (Grant Nos. 31571171, 31600867, and 31100838), the Shanghai Natural Science Foundation (Grant No. 15ZR1414900), the Key Laboratory of Medical Electrophysiology (Southwest Medical University) of Ministry of Education of China (Grant No. 201502), and the Young Teachers of Shanghai Universities Training Program.

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  1. Jiaying Chen and Can Zhang contributed equally to this work.

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  1. School of Life Sciences, Shanghai University, Shanghai, 200444, People’s Republic of China

    Jiaying Chen, Can Zhang, Yang Mi, Fuxue Chen & Dongshu Du

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  1. Jiaying Chen
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Correspondence to Fuxue Chen or Dongshu Du.

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Chen, J., Zhang, C., Mi, Y. et al. CREB1 regulates glucose transport of glioma cell line U87 by targeting GLUT1. Mol Cell Biochem 436, 79–86 (2017). https://doi.org/10.1007/s11010-017-3080-3

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