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Antitumor and antioxidant role of Chrysaora quinquecirrha (sea nettle) nematocyst venom peptide against ehrlich ascites carcinoma in Swiss Albino mice

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Abstract

This investigation aims to evaluate the antitumor and antioxidant potential of Chrysaora quinquecirrha (sea nettle) nematocyst venom on Ehrlich ascites carcinoma (EAC) tumor model. Tumor was induced in mice by intraperitoneal injection of EAC cells. The antitumor effect of sea nettle nematocyst venom (SNV) peptide was evaluated by assessing in vitro cytotoxicity, survival time, hematological, and antioxidant parameters. Intraperitoneal injection of SNV peptide increased the survival time of the EAC-bearing mice. The SNV peptide brought back the altered levels of the hematological and antioxidant parameters in a dose dependent manner in EAC-bearing mice. The results were comparable to that of the result obtained from the animals treated with the standard drug 5-fluorouracil (20 mg/kg bw). Thus, present study revealed that SNV peptide possessed significant antitumor and antioxidant activity.

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Authors and Affiliations

  1. Department of Biochemistry and Biotechnology, Annamalai University, Annamalainagar, 608 002, Tamil Nadu, India

    Elumalai Balamurugan, Bandugula Venkata Reddy & Venugopal Padmanaban Menon

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  1. Elumalai Balamurugan
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  2. Bandugula Venkata Reddy
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  3. Venugopal Padmanaban Menon
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Correspondence to Venugopal Padmanaban Menon.

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Balamurugan, E., Reddy, B.V. & Menon, V.P. Antitumor and antioxidant role of Chrysaora quinquecirrha (sea nettle) nematocyst venom peptide against ehrlich ascites carcinoma in Swiss Albino mice. Mol Cell Biochem 338, 69–76 (2010). https://doi.org/10.1007/s11010-009-0339-3

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