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CandiVF – Candida albicans Virulence Factor Database

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Abstract

Candida albicans is a pathogen commonly infecting patients who receive immunosuppressive drug therapy, long-term catheterization, or those who suffer from acquired immune deficiency syndrome (AIDS). The major factor accountable for pathogenicity of C. albicans is host immune status. Various virulence molecules, or factors, of are also responsible for the disease progression. Virulence proteins are published in public databases but they normally lack detailed functional annotations. We have developed CandiVF, a specialized database of C. albicans virulence factors (http://antigen.i2r.a-star.edu.sg/Templar/DB/CandiVF/) to facilitate efficient extraction and analysis of data aimed to assist research on immune responses, pathogenesis, prevention, and control of candidiasis. CandiVF contains a large number of annotated virulence proteins, including secretory, cell wall-associated, membrane, cytoplasmic, and nuclear proteins. This database has in-built bioinformatics tools including keyword and BLAST search, visualization of 3D-structures, HLA-DR epitope prediction, virulence descriptors, and virulence factors ontology.

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Authors and Affiliations

  1. Department of Microbiology, Faculty of Science, Mahidol University, Bangkok, Thailand

    Songsak Tongchusak & Sansanee C. Chaiyaroj

  2. Institute for Infocomm Research, 21 Heng Mui Keng Terrace, Singapore

    Songsak Tongchusak, Anitha Veeramani, Judice L. Y. Koh & Vladimir Brusic

  3. Australian Centre for Plant Functional Genomics, School of Land and Food Sciences, and Institute for Molecular Bioscience, University of Queensland, Brisbane, 4072, Queensland, Australia

    Vladimir Brusic

Authors
  1. Songsak Tongchusak
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  2. Sansanee C. Chaiyaroj
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  3. Anitha Veeramani
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  4. Judice L. Y. Koh
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  5. Vladimir Brusic
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Corresponding author

Correspondence to Vladimir Brusic.

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Tongchusak, S., Chaiyaroj, S.C., Veeramani, A. et al. CandiVF – Candida albicans Virulence Factor Database. Int J Pept Res Ther 11, 271–277 (2005). https://doi.org/10.1007/s10989-005-9268-5

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  • DOI: https://doi.org/10.1007/s10989-005-9268-5

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