Abstract
Locked Nucleic Acid (LNA) is a novel, third generation DNA analogue that has the potentialto impact strongly on the future development of a diversity of nucleic acid based technologies.The present chapter reviews the known biochemical properties of LNA and exemplifies how thesehave been used to improve both DNA diagnostic technologies and antisense therapeutics.
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Ørum, H., Wolter, A. & Kongsbak, L. Locked nucleic acids (LNA) and medical applications. Int J Pept Res Ther 10, 325–334 (2003). https://doi.org/10.1007/s10989-004-4905-y
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DOI: https://doi.org/10.1007/s10989-004-4905-y