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Thermal behaviour of some biological active perchlorate complexes with a triazolopyrimidine derivative

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Abstract

In order to modulate their biological activity in relation with microbial and mammalian cells, new compounds of type M(pmtp)(ClO4)2·nH2O (M: Co, Ni, Cu, Zn; pmtp: 5-phenyl-7-methyl-1,2,4-triazolo[1,5-a]pyrimidine) were synthesised and characterised by chemical analysis, FAB-MS, IR, UV–Vis–NIR, EPR spectroscopy, cyclic voltammetry and magnetic data at room temperature. The thermal behaviour of these derivatives was also investigated by TG–DSC/MS measurements to evidence the changes induced by heating and also the thermodynamics effects that accompany them. Processes as water elimination, perchlorate decomposition, fragmentation and oxidative degradation of the triazolopyrimidine species were observed during the thermal studies. The in vitro screening of the antimicrobial activity was performed against Gram positive (S. aureus, B. subtilis) and Gram negative (E. coli, K. pneumoniae, P. aeruginosa), both reference and clinical multidrug-resistant bacterial strains and Candida albicans fungal strain. The copper(II) complex was the most active against planktonic microbial cells, exhibiting minimum inhibitory concentration values in the range of 31–125 μg mL−1. Remarkably, all complexes showed an inhibitory activity against biofilm development on the inert substratum, showing a promising potential for the design of new efficient anti-biofilm strategies.

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Acknowledgements

The authors thank for magnetic measurements at room temperature to researcher Nicolae Stanică, from “Ilie Murgulescu” Physical Chemistry Institute of Romanian Academy.

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Authors and Affiliations

  1. Department of Inorganic Chemistry, Faculty of Chemistry, University of Bucharest, 90-92 Panduri Str., 050663, Bucharest, Romania

    Mihaela Badea, Larisa Calu & Rodica Olar

  2. Cellular Dynamics and Flow Cytometry Department, National Institute R&D for Biological Sciences, 296 Splaiul Independentei, 060031, Bucharest, Romania

    Larisa Calu

  3. Department of Inorganic Chemistry, Faculty of Chemistry and Chemical Technology, University of Ljubljana, Večna pot 113, 1000, Ljubljana, Slovenia

    Nataša Čelan Korošin

  4. Department of Analytical Chemistry, Faculty of Chemistry, University of Bucharest, 90-92 Panduri Str, 050663, Bucharest, Romania

    Iulia Gabriela David

  5. Department of Microbiology, Faculty of Biology, University of Bucharest, 1-3 Aleea Portocalilor St., 60101, Bucharest, Romania

    Mariana Carmen Chifiriuc

  6. Research Institute of the University of Bucharest, ICUB, Splaiul Independentei 91-95, Bucharest, Romania

    Mariana Carmen Chifiriuc

  7. Stefan S Nicolau Institute of Virology, 285 Mihai Bravu Ave., Bucharest, Romania

    Coralia Bleotu

  8. “Ilie Murgulescu” Physical Chemistry Institute, Romanian Academy, 202 Splaiul Independentei, 77208, Bucharest, Romania

    Gabriela Ionita

  9. 3S-Pharmacological Consultation and Research GmbH, 1 Koenigsbergerstrasse, 27243, Harpstedt, Germany

    Luigi Silvestro & Martin Maurer

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  1. Mihaela Badea
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  2. Larisa Calu
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  3. Nataša Čelan Korošin
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  4. Iulia Gabriela David
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  5. Mariana Carmen Chifiriuc
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  6. Coralia Bleotu
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Correspondence to Rodica Olar.

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Badea, M., Calu, L., Korošin, N.Č. et al. Thermal behaviour of some biological active perchlorate complexes with a triazolopyrimidine derivative. J Therm Anal Calorim 134, 665–677 (2018). https://doi.org/10.1007/s10973-018-7134-x

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  • DOI: https://doi.org/10.1007/s10973-018-7134-x

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