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Stability study of α-toc/β-CD powders obtained by microwave heating and encapsulation process

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Abstract

The α-tocopherol (α-toc) degrades faster than both γ- and δ-toc; its degradation rate is 10 times faster than δ-toc. The foremost factors that could affect the stability of vitamins upon storage are light, oxygen, and heat. Thus, this study aimed to investigate the thermal, storage, and physical stability of the α-tocopherol/β-cyclodextrin (α-toc/β-CD) powder obtained via microwave heating and encapsulation process. DSC, TG, and DTG were performed for thermal stability characterizations, while storage study was performed to investigate the stability of the encapsulated and non-encapsulated α-toc stored at 5, 28, and 50 °C for 42 days. The results obtained were then fitted with first-order degradation kinetic model to obtain the half-life for each sample. The physical stability in terms of flowability and compressibility was also studied during the storage. Encapsulation of α-toc into β-CD has successfully increased the thermal stability of α-toc to a higher decomposition temperature from 280 to 300 °C. The storage study showed that the encapsulation of α-toc by β-CD using the microwave technique has successfully improved the shelf life of α-toc with the half-life of 990, 523 and 126 days for samples stored at 5, 28, and 50 °C, respectively, with a good flow powder characteristics except for powder stored at 50 °C which showed passable flow powder characteristics after 42 days of storage.

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Acknowledgements

The authors gratefully acknowledge the financial support provided by the Ministry of Science, Technology and Innovation Malaysia and Research Management Centre, UTM.

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Authors and Affiliations

  1. Bioprocess and Polymer Engineering Department, Faculty of Chemical and Energy Engineering, Universiti Teknologi Malaysia (UTM), 81310, Johor Bahru, Johor, Malaysia

    Siti Nur Hidayah Mohamad, Ida Idayu Muhamad, Nozieana Khairuddin & Yanti Maslina Mohd Jusoh

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  1. Siti Nur Hidayah Mohamad
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  2. Ida Idayu Muhamad
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  4. Yanti Maslina Mohd Jusoh
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Correspondence to Ida Idayu Muhamad.

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Mohamad, S.N.H., Muhamad, I.I., Khairuddin, N. et al. Stability study of α-toc/β-CD powders obtained by microwave heating and encapsulation process. J Therm Anal Calorim 130, 1473–1480 (2017). https://doi.org/10.1007/s10973-017-6526-7

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