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Thermal behaviour and antimicrobial assay of some new zinc(II) 2-aminobenzoate complex compounds with bioactive ligands

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Abstract

New zinc(II) 2-aminobenzoate complexes with general formula Zn(2-NH2benz)2(L)2 (where 2-NH2benz is 2-aminobenzoate, and L is phenazone, N-methylnicotinamide, nicotinamide and isonicotinamide) were prepared and characterized by elemental analysis and by FTIR spectroscopy. The stability and thermal behaviour of the compounds were studied by thermal analysis techniques (TG/DTG, DTA), and the decomposition reactions were proposed. The decomposition of the studied compounds is always a multistep process, when after the release of the bioactive ligand, 2-aminobenzenecarbaldehyde, 2-aminobenzene and carbon dioxide were evolved. The solid intermediate compounds were confirmed by FTIR spectroscopy, and the volatile products were identified by mass spectrometry. The final solid product of thermal decompositions was zinc oxide, which was confirmed by XRD and FTIR analysis. The non-isothermal kinetic investigation of Zn(2-NH2benz)2(mnad)2 decomposition in air was performed by means of isoconversional methods, for a better understanding of the undergoing processes. The antimicrobial assay was carried out comparatively for the investigated compounds; they have higher biological activity towards Staphylococcus aureus, Escherichia coli and Candida albicans in comparison with zinc(II) 4-bromobenzoates.

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Acknowledgements

The authors would like to thank Prof. Vladimir Zelenak and Prof. Petre Rotaru for the help they provided for the experimental (thermal analysis measurements) part of this research.

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Science, P. J. Šafárik University, Moyzesova 11, 04154, Košice, Slovak Republic

    Annamária Krajníková, Katarína Győryová & Katarína Homzová

  2. Laser Department, INFLPR-National Institute for Laser, Plasma and Radiation Physics, Bvd. Atomistilor, Nr. 409, Magurele (Ilfov), Bucharest, Romania

    Andrei Rotaru

  3. Faculty of Dentistry, University of Medicine and Pharmacy, Petru Rareş Street, Nr. 2-4, Craiova, Romania

    Horia Octavian Manolea

  4. Institute of Macromolecular Chemistry, AS CR, Heyrovsky Sq. 2, 162 06, Prague 6, Czech Republic

    Jana Kovářová

  5. Department of Biochemistry and Microbiology, Slovak University of Technology, Radlinského 9, 812 37, Bratislava, Slovak Republic

    Daniela Hudecová

Authors
  1. Annamária Krajníková
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  2. Andrei Rotaru
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  3. Katarína Győryová
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  4. Katarína Homzová
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  5. Horia Octavian Manolea
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  6. Jana Kovářová
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  7. Daniela Hudecová
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Correspondence to Andrei Rotaru.

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Krajníková, A., Rotaru, A., Győryová, K. et al. Thermal behaviour and antimicrobial assay of some new zinc(II) 2-aminobenzoate complex compounds with bioactive ligands. J Therm Anal Calorim 120, 73–83 (2015). https://doi.org/10.1007/s10973-014-4212-6

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  • DOI: https://doi.org/10.1007/s10973-014-4212-6

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