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213Bi production and complexation with new picolinate containing ligands

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Abstract

Binding of bismuth cation with two newly synthesized picolinate containing acyclic (L1) and macrocyclic (L2) ligands was studied. Both ligands demonstrate complex formation with Bi3+ under ambient conditions with high complexation constants. Serum stability of the complexes was investigated in serum protein excess of 10- and 100-times. Experiments with no-carrier-added radiobismuth (207Bi and 213Bi) were performed. A one-column 225Ac/213Bi generator system, based on Ac resin (Triskem Inc.), was tested. The overall yield of 213Bi was exceeding 85% with 225Ac breakthrough below 10−4%.

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Acknowledgements

This work has been supported by the Russian Science Foundation under Contract № 17-73-10465 (225Ac producing and 225Ac/213Bi generator developing) and Russian Foundation for Basic Research Contract № 18-33-20152 (synthesis of ligands and complexation study).

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Authors and Affiliations

  1. Lomonosov Moscow State University, GSP-1, Leninskie Gory, Moscow, Russian Federation, 119991

    I. L. Sinenko, T. P. Kalmykova, D. V. Likhosherstova, B. V. Egorova, A. N. Vasiliev, V. S. Ostapenko, O. A. Fedorova & S. N. Kalmykov

  2. Institute for Nuclear Research of Russian Academy of Sciences, 60th October Anniversary Prospect, 7a, Moscow, Russian Federation, 117312

    A. N. Vasiliev, S. V. Ermolaev, E. V. Lapshina & V. S. Ostapenko

  3. A. N. Nesmeyanov Institute of Organoelement Compounds of Russian Academy of Sciences, Vavilova, 28, GSP-1, Moscow, Russian Federation, 119991

    A. D. Zubenko & O. A. Fedorova

  4. Mendeleev University of Chemistry and Technology of Russia, Miusskaya sqr., 9, Moscow, Russian Federation, 125047

    O. A. Fedorova

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  1. I. L. Sinenko
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  2. T. P. Kalmykova
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  6. A. N. Vasiliev
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  8. E. V. Lapshina
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Correspondence to A. N. Vasiliev.

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Sinenko, I.L., Kalmykova, T.P., Likhosherstova, D.V. et al. 213Bi production and complexation with new picolinate containing ligands. J Radioanal Nucl Chem 321, 531–540 (2019). https://doi.org/10.1007/s10967-019-06610-w

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