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Utilization of L-serinyl derivate to preparing triple stimuli-responsive hydrogels for controlled drug delivery

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Abstract

Environmentally responsive hydrogels are widely used in various applications. Facile synthesis of multiply stimuli-responsive hydrogels is necessary. Herein, a triple pH-, thermo- and ion-sensitive hydrogel, shorted as HSP, was synthesized by aqueous radical polymerization using L-serinyl acrylate as a monomer and PEG180DMA as a crosslinker. The compositions and microstructures of HSP are characterized by FT-IR, 1H NMR and SEM. The swelling ratio of HSP is the lowest at pH = 3.0 while increases sharply far away from this pH value. Meanwhile, HSP expands with elevated temperatures or ionic strengths, and reaches a plateau when they above 60 °C or 3.0 mol/L, respectively. In addition, these swelling processes are reversible under alternative changing in extern stimuli, and these cycles can be repeated at least 5 times. Furthermore, the release of sodium salicylate can be easily mediated by pH values, temperatures and ion concentrations, all above indicating that HSP is a promising material for controlled drug delivery.

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Acknowledgements

The authors appreciate financial support from Key research projects of North Minzu University(2019KJ14), the National Natural Science Foundation of China (21464001), Specialized Research Fund for Outstanding Young Teachers in Ningxia Higher Education Institutions (NGY2018-165), Natural Science Foundation of Ningxia Province (NZ 17099), Ningxia low-grade resource high value utilization and environmental chemical integration technology innovation team project, and Foundation of State Key Laboratory of High-efficiency Utilization of Coal and Green Chemical Engineering(Grant No.2017-K24). The authors declare no competing financial interest.

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  1. College of Chemistry and Chemical Engineering, North Minzu University, Yinchuan, 750021, Ningxia, China

    Chun Hui Luo, Xin Xin Sun, Feng Wang & Ning Wei

  2. Key Laboratory of Chemical Engineering and Technology, State Ethnic Affairs Commission, North Minzu University, Yinchuan, 750021, Ningxia, China

    Chun Hui Luo

  3. State Key Laboratory of High-efficiency Utilization of Coal and Green Chemical Engineering, Ningxia University, Yinchuan, 750021, China

    Fa Liang Luo

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  1. Chun Hui Luo
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Luo, C.H., Sun, X.X., Wang, F. et al. Utilization of L-serinyl derivate to preparing triple stimuli-responsive hydrogels for controlled drug delivery. J Polym Res 26, 280 (2019). https://doi.org/10.1007/s10965-019-1976-1

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