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Synthesis, characterization and degradation of poly(dl-lactide)-block-polyvinylpyrrolidone-block-poly(dl-lactide) copolymers

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Abstract

A new kind of A-B-A block copolymers with good biocompatibility and adjustable degradability was synthesized by ring-opening polymerization, in which DL-lactide polymerized and grew from the two ends of polyvinylpyrrolidone (PVP). The well-defined triblock structures of copolymers were characterized by GPC, 1H NMR, FTIR and DSC. There were two pronounced glass transition temperatures which showed apparent microphase separations between hydrophilic PVP segment and hydrophobic poly(dl-lactide) (PDLLA) segments. The hydrolytic degradation of PDLLA and copolymers in phosphate buffer solution (PBS, pH = 7.4) showed that the degradation rate of copolymers apparently became faster in comparison with that of PDLLA homopolymer, and increased with increasing PVP content. The measurements through 1H NMR and FTIR showed that the degraded fragments contained PDLLA oligomers, lactates and soluble chains composed of PVP blocks attached with short PDLLA ones.

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References

  1. Gupta AP, Kumar V (2007) Eur Polym J 43(10):4053 doi:10.1016/j.eurpolymj.2007.06.045

    Article  CAS  Google Scholar 

  2. Hakkarainen M, Albertsson AC, Karlsson S (1996) Polym Degrad Stabil 52(3):283 doi:10.1016/0141-3910(96)00009-2

    Article  CAS  Google Scholar 

  3. Zhang HW, Cui WJ, Bei JZ et al (2006) Polym Degrad Stabil 91(9):1929 doi:10.1016/j.polymdegradstab.2006.03.004

    Article  CAS  Google Scholar 

  4. Muriel S, Jean C, Michel V (2006) Polym Degrad Stabil 91(11):2554 doi:10.1016/j.polymdegradstab.2006.05.009

    Article  Google Scholar 

  5. Venkatraman SS, Pan J, Feng M et al (2005) Int J Pharm 298:219 doi:10.1016/j.ijpharm.2005.03.023

    Article  CAS  Google Scholar 

  6. Ryotaro K, Hiraku OBB, Yoshiharu M (2007) Eur J Pharm Biopharm 67(1):9 doi:10.1016/j.ejpb.2007.01.012

    Article  Google Scholar 

  7. Hoque ME, Hutmacher DW, Feng W et al (2005) J Biomater Sci Polym Ed 16:1995 doi:10.1163/156856205774576709

    Article  Google Scholar 

  8. Long Z, Ling X, Hiroshi M et al (2006) Carbohydr Polym 64(3):473 doi:10.1016/j.carbpol.2005.12.014

    Article  Google Scholar 

  9. Kulkarni RK, Moore EG, Hegyeli AF et al (1971) J Biomed Mater Res 5(3):169 doi:10.1002/jbm.820050305

    Article  CAS  Google Scholar 

  10. Yuan ML, Liu D, Xiong CD et al (1999) Eur Polym J 35(12):2139 doi:10.1016/S0014-3057(99)00016-6

    Article  CAS  Google Scholar 

  11. Walter R (1955) DE Patent 922,378 Sept 1955

Download references

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Authors and Affiliations

  1. South China University of Technology, Guangzhou, China

    Lei Xiong, Hong Wei Jiang & Di Zhen Wang

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  1. Lei Xiong
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  2. Hong Wei Jiang
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  3. Di Zhen Wang
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Correspondence to Lei Xiong.

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Xiong, L., Jiang, H.W. & Wang, D.Z. Synthesis, characterization and degradation of poly(dl-lactide)-block-polyvinylpyrrolidone-block-poly(dl-lactide) copolymers. J Polym Res 16, 191–197 (2009). https://doi.org/10.1007/s10965-008-9218-y

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  • DOI: https://doi.org/10.1007/s10965-008-9218-y

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