Abstract
In this article, a pH sensitive semi-interpenetrating network (SIPN) hydrogel based on methacrylic acid, BSA, and PEG was prepared by UV initiated free radical polymerization. The swelling behavior and pH sensitivity of these hydrogels were studied in detail. With the increase in pH of the aqueous solution from 1.7 to 9.23, the swelling ratio of these hydrogels increased accordingly. The effect of BSA and crosslinker (BIS) content on the swelling behavior was more complicated, and the results were shown in the text.
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K. Y. Lee and D. J. Mooney, Hydrogels for tissue engineering, Chem. Rev., 101(7), 1869–1879 (2001).
Y. Qiu and K. Park, Environment-sensitive hydrogels for drug delivery, Adv. Drug Del. Rev., 53, 321–339 (2001).
K. T. Nguyen and J. L. West, Photopolymerizable hydrogels for tissue engineering applications, Biomaterials, 23, 4307–4314 (2002).
R. K. Drummond, J. Klier, J. A. Alameda and N. A. Peppas, Preparation of poly(methacrylic acid-g-ethylene oxide) microspheres, Macromolecules, 22, 3816–3818 (1989).
M. Torres-Lugo, M. Garcia, R. Record and N. A. Peppas, Physicochemical behavior and cytotoxic effects of P(methacrylic acid-g-ethylene glycol) nanospheres for oral delivery of proteins, J. Control. Release, 80, 197–205 (2002).
M. Torres-Lugo and N. A. Peppas, Molecular dosing and in vitro studies of novel pH-sensitive hydrogels for the oral delivery of calcitonin, Macromolecules, 32, 6646–6651 (1999).
H. Ichikawa, M. Torres-Lugo and N. A. Peppas, Novel pH-sensitive hydrogels for oral peptide delivery: in vitro evaluation of their cytocompatibility and insulin transport effect in caco-2 cell monolayers, AAPS Pharm. Sci., S3287 (2000).
D. S. Bag, S. Alam and G. N. Mathur, Terpolymer smart gels: synthesis and characterizations, Smart Materials Structures, 13, 1258–1262 (2004).
S. L. Zhou, S. Matsumoto, H. D. Tian, H. Yamane, A. Ojida, S. Kiyonaka and I. Hamachi, PH-responsive shrinkage/swelling of a supramolecular hydrogel composed of two small amphiphilic molecules, Chem. Euro. J., 11, 1130–1136 (2005).
X. C. Xiao, L. Y. Chu, W. M. Chen, S. Wang and Y. Li, Positively thermo-sensitive monodisperse core-shell microspheres, Adv. Funct. Mater., 13, 847–852 (2003).
P. Markland, Y. Zhang, G. L. Amidon and V. C. Yang, A pH- and ionic strength-responsive polypeptide hydrogel: synthesis, characterization, and preliminary protein release studies, J. Biomed. Mater. Res., 47, 595–602 (1999).
K. R. Kamath and K. Park, Biodegradable hydrogels in drug delivery, Adv. Drug Del. Rev., 11, 59–84 (1993).
S. Murdan, Electro-responsive drug delivery from hydrogels, J. Control. Release, 92, 1–17 (2003).
W. F. Lee and R. J. Chiu, Thermoreversible hydrogels. XVIII. Synthesis, swelling characteristics, and diffusion behaviors of porous, ionic, thermosensitive hydrogels, J. Appl. Polym. Sci., 90, 2214–2223 (2003).
D. Saraydin, E. Karadag and O. Guven, Acrylamide/Maleic acid hydrogels, Polym, Adv. Technol., 6, 719–726 (1995).
H. Xu, P. T. Ding, G. Wei, G. S. Zhou and J. M. Zheng, Equilibrium swelling and solute diffusion characteristics of poly(methacrylic acid-co-poloxamer) hydrogel, J. Chin. Pharm. Sci., 10(4), 203–207 (2001).
B. Kim, K. L. Flamme and N. A. Peppas, Dynamic swelling behavior of pH-sensitive anionic hydrogels used for protein delivery, J. Appl. Polym. Sci., 89, 1606–1613 (2003).
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Deng HX is the co-first author for this article.
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Chao, G., Deng, H., Huang, Q. et al. Preparation and Characterization of pH Sensitive Semi-interpenetrating Network Hydrogel Based on Methacrylic Acid, Bovine Serum Albumin (BSA), and PEG. J Polym Res 13, 349–355 (2006). https://doi.org/10.1007/s10965-006-9050-1
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DOI: https://doi.org/10.1007/s10965-006-9050-1