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Biology of Glucose Transport in the Mammary Gland

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Journal of Mammary Gland Biology and Neoplasia Aims and scope Submit manuscript

Abstract

Glucose is the major precursor of lactose, which is synthesized in Golgi vesicles of mammary secretory alveolar epithelial cells during lactation. Glucose is taken up by mammary epithelial cells through a passive, facilitative process, which is driven by the downward glucose concentration gradient across the plasma membrane. This process is mediated by facilitative glucose transporters (GLUTs), of which there are 14 known isoforms. Mammary glands mainly express GLUT1 and GLUT8, and GLUT1 is the predominant isoform with a K m of ~10 mM and transport activity for mannose and galactose in addition to glucose. Mammary glucose transport activity increases dramatically from the virgin state to the lactation state, with a concomitant increase in GLUT expression. The increased GLUT expression during lactogenesis is not stimulated by the accepted lactogenic hormones. New evidence indicates that a possible low oxygen tension resulting from increased metabolic rate and oxygen consumption may play a major role in stimulating glucose uptake and GLUT1 expression in mammary epithelial cells during lactogenesis. In addition to its primary presence on the plasma membrane, GLUT1 is also expressed on the Golgi membrane of mammary epithelial cells and is likely involved in facilitating the uptake of glucose and galactose to the site of lactose synthesis. Because lactose synthesis dictates milk volume, regulation of GLUT expression and trafficking represents potentially fruitful areas for further research in dairy production. In addition, this research will have pathological implications for the treatment of breast cancer because glucose uptake and GLUT expression are up-regulated in breast cancer cells to accommodate the increased glucose need.

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Abbreviations

2-DG:

2-deoxy-D-glucose

3-O-MG:

3-0-methyl-D-glucose

α-LA:

α-lactalbumin

β4Gal-T1:

β1,4-galactosyltransferase

G6P:

Glucose-6-phosphate

GLUT:

Facilitative glucose transporter

MBF:

Mammary blood flow

MECs:

Mammary alveolar epithelial cells

NADPH:

Nicotinamide adenine dinucleotide phosphate

SGLT:

Na+/glucose cotransporter

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Acknowledgments

I am indebted to the students, fellows, and collaborators for their contributions to the cited works of my laboratory at the University of Vermont. The work of my laboratory has been supported by various grants from the USDA, including the National Research Initiative Competitive Grants no. 2005-35206-15267 and no. 2007-35206-18037 from the USDA National Institute of Food and Agriculture.

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  1. Laboratory of Lactation and Metabolic Physiology, Department of Animal Science, University of Vermont, 211 Terrill Building, 570 Main Street, Burlington, VT, 05405, USA

    Feng-Qi Zhao

  2. Institute of Dairy Science, College of Animal Sciences, Zhejiang University, Hangzhou, Zhejiang, 310029, China

    Feng-Qi Zhao

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Zhao, FQ. Biology of Glucose Transport in the Mammary Gland. J Mammary Gland Biol Neoplasia 19, 3–17 (2014). https://doi.org/10.1007/s10911-013-9310-8

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