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Mesenchymal Stem Cells in the Pathogenesis and Therapy of Breast Cancer

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Journal of Mammary Gland Biology and Neoplasia Aims and scope Submit manuscript

Abstract

Mesenchymal stem cells (MSCs) are a heterogeneous mix of stromal stem cells that can give rise to cells of mesodermal lineages, namely adipocytes, osteocytes and chondrocytes. They can home to sites of injury where they promote the repair and regeneration of damaged tissues. MSCs also home to sites of tumorigenesis, and as such, are utilized as efficient cellular vehicles for the delivery of anti-neoplastic therapeutics. Recently, MSCs within the tumor microenvironment have been shown to contribute to the desmoplastic reaction and to facilitate tumor formation and progression, sparking renewed interest in their pro-tumorigenic attributes and their roles as tumor stromal cells. Here, we describe the evidence linking MSCs to inflammatory processes and breast cancer development, and discuss their newly discovered physiological roles in the context of the tumor microenvironment.

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Abbreviations

CFU-F:

Colony forming unit-fibroblastic

MSC:

Mesenchymal stem cell

GvHD:

Graft-versus-host disease

IFN-γ:

Interferon-β

CD:

Cluster of differentiation

HLA-DR:

Human leukocyte antigen-DR

MHC:

Major histocompatibility complex

NANOG:

NK-2 type homeodomain gene

OCT-4:

Octamer binding transcription factor 4

SOX2:

Sex determining region Y-box 2

TGF-β:

Tumor growth factor-β

TGF-βR1:

Tumor growth factor-β receptor 1

SMAD3:

Mothers against decapentaplegic homolog 3

Foxp3:

Forkhead box p3

IBD:

Inflammatory bowel disease

MMP:

Matrix metalloproteinase

MCP-1:

Monocyte-derived protein 1

HDGF:

Hepatoma-derived growth factor

uPA:

Urokinase plasminogen activator

uPAR:

Urokinase plasminogen activator receptor

HDAC:

Histone deacetylase

FGF2:

Fibroblast growth factor 2

VEGF:

Vascular endothelial growth factor

IL:

Interleukin

STAT3:

Signal transducer and activator of transcription 3

CCL5:

C-C motif ligand 5

Th2:

T helper 2

SDF-1:

Stromal-cell derived factor 1

CRAds:

Conditionally replicating oncolytic adenoviruses

TRAIL:

Tumor necrosis factor-related apoptosis-inducing ligand

HSV-tk:

Herpes simplex virus-thymidine kinase

CD:

Cytosine deaminase

5-FC:

5-Fluorocytosine

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Acknowledgements

Our research is supported by start-up funds from the Beth Israel Deaconess Medical Center, T32 Institutional NRSA Research Training Grants, and the Sydney Kimmel Cancer Research Foundation. AEK is a 2010 Kimmel Scholar.

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  1. Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02215, USA

    Christelle P. El-Haibi & Antoine E. Karnoub

  2. Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Center for Life Science 0634, 3 Blackfan Circle, Boston, MA, 02215, USA

    Antoine E. Karnoub

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  1. Christelle P. El-Haibi
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Correspondence to Antoine E. Karnoub.

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El-Haibi, C.P., Karnoub, A.E. Mesenchymal Stem Cells in the Pathogenesis and Therapy of Breast Cancer. J Mammary Gland Biol Neoplasia 15, 399–409 (2010). https://doi.org/10.1007/s10911-010-9196-7

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