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Gentamicin Loaded Zn2(bdc)2(dabco) Frameworks as Efficient Materials for Drug Delivery and Antibacterial Activity

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Abstract

New drug delivery systems are very helpful in diagnosis and treatment of diseases through controlled and targeted drug delivery. They can increase bioavailability of drugs and reduce their side effects. Metal–organic frameworks (MOFs) are alternative drug delivery systems, which are suitable for targeted drug delivery due to their adjustable pore sizes and compatibility by adding some functional groups. Application of these compounds permits simultaneous use of several advantages including biocompatibility, the ability to absorb large amounts of drugs and control drug release. The present study was designed to provide Zn2(bdc)2(dabco) MOF and evaluate its performance in absorbing and releasing gentamicin. Characterization methods, such as FTIR, XRD, SEM, BET, UV–Vis spectroscopy and TGA, were employed to characterize the gentamicin-loaded Zn2(bdc)2(dabco) structure. The amount of drug release from Zn2(bdc)2(dabco) was measured in buffer solutions with 7.4 and 5.0 pHs. Furthermore, antibacterial properties of the drug, MOF and drug-loaded MOF have been investigated against Gram-positive and Gram-negative bacteria. This study shows the potential of using Zn2(bdc)2(dabco) frameworks for controlled release of antibiotic drugs.

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Acknowledgements

This work has been financially supported by Azarbaijan Shahid Madani University under the grant number 96/603.

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Science, Azarbaijan Shahid Madani University, Tabriz, Iran

    Behzad Soltani

  2. Faculty of Pharmacy, Hormozgan University of Medical Science, Bandar Abbas, Iran

    Hafezeh Nabipour & Navid Ahmadi Nasab

Authors
  1. Hafezeh Nabipour
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  2. Behzad Soltani
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  3. Navid Ahmadi Nasab
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Correspondence to Hafezeh Nabipour or Behzad Soltani.

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Nabipour, H., Soltani, B. & Ahmadi Nasab, N. Gentamicin Loaded Zn2(bdc)2(dabco) Frameworks as Efficient Materials for Drug Delivery and Antibacterial Activity. J Inorg Organomet Polym 28, 1206–1213 (2018). https://doi.org/10.1007/s10904-018-0781-3

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  • DOI: https://doi.org/10.1007/s10904-018-0781-3

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