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Copper-doped Lanthanide Coordination Polymers as Luminescent Nanoenzyme for Ratiometric Sensing of H2O2 and Glutathione

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Abstract

Design and fabrication of integrated multifunctional probes with intrinsic catalytic and detection abilities is of great importance to simplify the operation in biosensing application with high sensitivity. Herein, dual-emitting lanthanide coordination polymers (Ln-CPs) were facilely prepared by self-assembly of guanine diphosphate (GDP), terephthalic acid (TA), Tb3+ and Cu2+ designated as Tb/Cu-GDP/TA CPs. The doped Cu2+ endowed CPs with obviously enhanced peroxidase mimicking activity compared with free Cu2+. In the presence of H2O2, the probe catalyzed the oxidation of TA generating a new blue fluorescent product, while the fluorescence of Tb3+ decreased simultaneously. Therefore, a new sensitive ratiometric fluorescent sensor for H2O2 has been developed with a good linear range from 0.01 to 300 μM and limit of 1.62 nM. Moreover, the proposed platform could be extended to GSH ratiometric assay in the presence of H2O2, and interestingly, the detection performance could be easily adjusted by adding different concentration of H2O2. This work will facilitate the development of luminescent nanoenzymes based on Ln-CPs to construct the simple ratiomatric sensing platform.

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Funding

This work was supported by the National Natural Science Foundation of China (Grant Nos. 22176179 and 42077389).

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Authors and Affiliations

  1. College of Chemistry, Zhengzhou University, Zhengzhou, 450001, PR China

    Xinru Wu, Chen Ruan, Xinyue Zhu, Lina Zou, Rong Wang & Gaiping Li

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  1. Xinru Wu
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  3. Xinyue Zhu
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Contributions

Xinru Wu: Conceptualization, Methodology, Validation, Resources, Data curation, Writing – original draft, Writing – review & editing. Chen Ruan: Formal analysis, Investigation. Xinyue Zhu: Formal analysis, Methodology, Investigation. Lina Zou: Formal analysis, Methodology, Investigation. Rong Wang: Formal analysis, Methodology, Investigation. Gaiping Li: Data curation, Writing – review & editing, Project administration.

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Correspondence to Gaiping Li.

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Highlights

• Cu(II)-doped Ln-CPs with fluorescent and catalytic functions were facilely synthesized through one-step self-assembly in aqueous solution.

• The Tb/Cu-GDP/TA CPs shew enhanced peroxidase-like activity and could directly ratiometric fluorescence sense of H2O2.

• With the help of H2O2, the Tb/Cu-GDP/TA CPs could be extended to GSH assay with adjustable LOD and linear range.

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Wu, X., Ruan, C., Zhu, X. et al. Copper-doped Lanthanide Coordination Polymers as Luminescent Nanoenzyme for Ratiometric Sensing of H2O2 and Glutathione. J Fluoresc (2024). https://doi.org/10.1007/s10895-024-03659-z

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