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Florescence Imaging Lung Cancer with a Small Molecule MHI-148

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Abstract

MHI-148 is a type of heptamethine cyanine dye that can cross the cytoplasmic membrane of lung cancer cells. Here we tested the cytotoxic, in vivo imaging of MHI-148 in lung-cancer nude mice model. Ex vivo imaging was also been measured by testing the major tissue fluorescence intensity. And, the small molecular compound MHI-148 had low cytotoxicity which could be visualized at 1 h post-injection in tumor. From ex vivo fluorescence imaging, the tumor showed the highest uptake of MHI-148 among all the selected organs expect for the time point of 2 h. MHI-148 could be used for effective imaging in lung cancer tissue with good stability and specificity, which suggested that MHI-148 could be an effective tumor clinical imaging agent.

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Acknowledgments

This research was supported by National Natural Science Foundation of China [81801737], Fundamental research fund for the Chinese Central Universities of Huazhong University of Science and Technology (HUST) [2017KFYXJJ246] and Research foundation of Wuhan Union Hospital [02.03.2017-306].

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Authors and Affiliations

  1. Department of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277 Jiefang Ave, Wuhan, 430022, Hubei Province, China

    Xiaotian Xia, Yongkang Gai, Hongyan Feng, Chunxia Qin, Yiling Song, Yongxue Zhang & Xiaoli Lan

  2. Hubei Province Key Laboratory of Molecular Imaging, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

    Xiaotian Xia, Yongkang Gai, Hongyan Feng, Chunxia Qin, Yiling Song, Yongxue Zhang & Xiaoli Lan

  3. Department of Radiology, University of Virginia, Charlottesville, VA, 22908, USA

    Dongfeng Pan

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  1. Xiaotian Xia
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Xia, X., Gai, Y., Feng, H. et al. Florescence Imaging Lung Cancer with a Small Molecule MHI-148. J Fluoresc 30, 1523–1530 (2020). https://doi.org/10.1007/s10895-020-02605-z

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