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A New Zn(II) Complex: Fluorescent Detection of Fe3+ Ions in Water and Prevention Effect on DVT By Regulating Platelets Numbers and Activity of Clotting Factor

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Abstract

[Zn(dima)(H2O)0.5]·H2O (1), a three-dimensional metal organic framework (MOF) with high porosity was formed by self-assembly of 4,6-di(1 h-imidazol-1-yl)isophthalic acid (H2dima) and Zn2+ ion. Owning to its excellent luminescence and excellent water stability, complex 1 can be used as a super sensitive sensor to detect Fe3+ ions via the behaviors of fluorescence quenching. At the same time, the mechanism for the fluorescence quenching is also further discussed. Furthermore, the prevention effect of the compound on the deep vein thrombosis of the lower extremities (DVT) after lower venous CHIVA surgery was evaluated in vivo. Firstly, the DVT animal models was constructed and the number of platelets was measured with flow cytometry and content of clotting factor IX and anticoagulant factor III was also detected with Lowry method after compound treatment. The molecular docking simulation results indicate that the Zn(II) complex has activity to protein docking pocket with different sizes.

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Acknowledgements

This work was supported by the Key research projects of Hebei Health Commission (20190407).

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Authors and Affiliations

  1. Department of Ultrasonography, Hebei General Hospital, Shijiazhuang, Hebei, China

    Yue-Ying Pei, Jie Gao, Xin Liu & Hong-Yuan Xue

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  1. Yue-Ying Pei
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  2. Jie Gao
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  3. Xin Liu
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  4. Hong-Yuan Xue
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Correspondence to Hong-Yuan Xue.

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Pei, YY., Gao, J., Liu, X. et al. A New Zn(II) Complex: Fluorescent Detection of Fe3+ Ions in Water and Prevention Effect on DVT By Regulating Platelets Numbers and Activity of Clotting Factor. J Fluoresc 30, 1241–1250 (2020). https://doi.org/10.1007/s10895-020-02594-z

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  • DOI: https://doi.org/10.1007/s10895-020-02594-z

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