Abstract
In the present work, we synthesized the carbon quantum dots (CQDs) by one step hydrothermal method using the dried beet powder as the carbon source without additional chemical reagents and functionalization. The as-prepared CQDs are quasi-spherical carbon nanoparticles with diameters of 4–8 nm as well as surface functional groups such as carboxyl and hydroxyl groups, and exhibit good water-solubility, biocompatibility, and strong fluorescence. It is confirmed that amoxicillin (AMO) could enhance the fluorescent intensity of CQDs, the I/I0 showed a linear correlation between the intensity of fluorescence and the concentration of AMO in a broad range. These superior properties render a potential application of the CQDs in biomedical.
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References
De Baere S, De Backer P (2007) Quantitative determination of amoxicillin in animal feed using liquid chromatography with tandem mass spectrometric detection. Anal Chim Acta 586:319–325. https://doi.org/10.1016/j.aca.2006.10.036
Bergamini MF, Teixeira MFS, Dockal ER et al (2006) Evaluation of different voltammetric techniques in the determination of amoxicillin using a carbon paste electrode modified with [N, N’-ethylenebis(salicylideneaminato)] oxovanadium(IV). J Electrochem Soc 153:E94–E98. https://doi.org/10.1149/1.2184035
Shah K, Hassan E, Ahmed F et al (2017) Novel fluorene-based supramolecular sensor for selective detection of amoxicillin in water and blood. Ecotoxicol Environ Saf 141:25–29. https://doi.org/10.1016/j.ecoenv.2017.03.003
Cohen ML (1992) Epidemiology of Drug Resistance: Implications for a Post-Antimicrobial Era. Science 257(80):1050–1055. https://doi.org/10.1126/science.257.5073.1050
Gonzales R, Bartlett JG, Besser RE et al (2001) Principles of appropriate antibiotic use for treatment of acute respiratory tract infections in adults: background, specific aims, and methods. Ann Emerg Med 37:690–697. https://doi.org/10.1067/S0196-0644(01)70087-X
Hoizey G, Lamiable D, Frances C et al (2002) Simultaneous determination of amoxicillin and clavulanic acid in human plasma by HPLC with UV detection. J Pharm Biomed Anal 30:661–666. https://doi.org/10.1016/S0731-7085(02)00289-3
Fuwei W, Jinghua Y, Ping D, Shenguang G (2010) Molecular imprinting-Chemiluminescence sensor for the determination of amoxicillin. Anal Lett 43:1033–1045. https://doi.org/10.1080/00032710903491104
Straub RF, Voyksner RD (1993) Determination of penicillin G, ampicillin, amoxicillin, cloxacillin and cephapirin by high-performance liquid chromatography-electrospray mass spectrometry. J Chromatogr A 647:167–181. https://doi.org/10.1016/0021-9673(93)83336-Q
Abdulghani AJ, Jasim HH, Hassan AS (2012) Determination of β-lactam antibiotics in pharmaceutical preparations by Uv-visible spectrophotometry atomic absorption and high performance liquid chromatography. Pakistan J Chem 2:150–160. https://doi.org/10.15228/2012.v02.i03.p08
Ojani R, Raoof J-B, Zamani S (2012) A novel voltammetric sensor for amoxicillin based on nickel-curcumin complex modified carbon paste electrode. Bioelectrochemistry 85:44–49. https://doi.org/10.1016/j.bioelechem.2011.11.010
Xu X, Ray R, Gu Y et al (2004) Electrophoretic analysis and purification of fluorescent single-walled carbon nanotube fragments. J Am Chem Soc 126:12736–12737. https://doi.org/10.1021/ja040082h
Hutton GAM, Martindale BCM, Reisner E (2017) Carbon dots as photosensitisers for solar-driven catalysis. Chem Soc Rev 46:6111–6123. https://doi.org/10.1039/C7CS00235A
Wang F, Chen P, Feng Y et al (2017) Facile synthesis of N-doped carbon dots/g-C3N4 photocatalyst with enhanced visible-light photocatalytic activity for the degradation of indomethacin. Appl Catal B Environ 207:103–113. https://doi.org/10.1016/j.apcatb.2017.02.024
Zhang J, Yu SH (2016) Carbon dots: large-scale synthesis, sensing and bioimaging. Mater Today 19:382–393. https://doi.org/10.1016/j.mattod.2015.11.008
Shangguan J, Huang J, He D et al (2017) Highly Fe3+-selective fluorescent Nanoprobe based on Ultrabright N/P Codoped carbon dots and its application in biological samples. Anal Chem 89:7477–7484. https://doi.org/10.1021/acs.analchem.7b01053
Hou J, Dong J, Zhu H et al (2015) A simple and sensitive fluorescent sensor for methyl parathion based on l-tyrosine methyl ester functionalized carbon dots. Biosens Bioelectron 68:20–26. https://doi.org/10.1016/j.bios.2014.12.037
Tan J, Zou R, Zhang J et al (2016) Large-scale synthesis of N-doped carbon quantum dots and their phosphorescence properties in a polyurethane matrix. Nano 8:4742–4747. https://doi.org/10.1039/C5NR08516K
Zhang C, Cui Y, Song L et al (2016) Microwave assisted one-pot synthesis of graphene quantum dots as highly sensitive fluorescent probes for detection of iron ions and pH value. Talanta 150:54–60. https://doi.org/10.1016/j.talanta.2015.12.015
Sharma S, Mehta SK, Kansal SK (2017) Highly fluorescent silver oxide/C-dots nanocomposite as selective and sensitive probe for highly efficient detection of Fe(III) ions. Sensors Actuators B Chem 243:1148–1156. https://doi.org/10.1016/j.snb.2016.12.100
Atchudan R, Edison TNJI, Chakradhar D et al (2017) Facile green synthesis of nitrogen-doped carbon dots using Chionanthus retusus fruit extract and investigation of their suitability for metal ion sensing and biological applications. Sensors Actuators B Chem 246:497–509. https://doi.org/10.1016/j.snb.2017.02.119
Wang J, Qiu F, Wu H et al (2017) Fabrication of fluorescent carbon dots-linked isophorone diisocyanate and β-cyclodextrin for detection of chromium ions. Spectrochim Acta Part A Mol Biomol Spectrosc 179:163–170. https://doi.org/10.1016/j.saa.2017.02.031
Tabaraki R, Abdi O, Yousefipour S (2017) Green and selective fluorescent sensor for detection of Sn (IV) and Mo (VI) based on boron and nitrogen-co-doped carbon dots. J Fluoresc 27:651–657. https://doi.org/10.1007/s10895-016-1994-x
Liu H, He Z, Jiang LP, Zhu JJ (2015) Microwave-assisted synthesis of wavelength-tunable Photoluminescent carbon Nanodots and their potential applications. ACS Appl Mater Interfaces 7:4913–4920. https://doi.org/10.1021/am508994w
Guo Y, Wang Z, Shao H, Jiang X (2013) Hydrothermal synthesis of highly fluorescent carbon nanoparticles from sodium citrate and their use for the detection of mercury ions. Carbon N Y 52:583–589. https://doi.org/10.1016/j.carbon.2012.10.028
Gonçalves HMR, Duarte AJ, Esteves da Silva JCG (2010) Optical fiber sensor for hg(II) based on carbon dots. Biosens Bioelectron 26:1302–1306. https://doi.org/10.1016/j.bios.2010.07.018
Yang K, Wang S, Wang Y et al (2017) Dual-channel probe of carbon dots cooperating with gold nanoclusters employed for assaying multiple targets. Biosens Bioelectron 91:566–573. https://doi.org/10.1016/j.bios.2017.01.014
Simões EFC, Esteves da Silva JCG, Leitão JMM (2015) Peroxynitrite and nitric oxide fluorescence sensing by ethylenediamine doped carbon dots. Sensors Actuators B Chem 220:1043–1049. https://doi.org/10.1016/j.snb.2015.06.072
Luo M, Hua Y, Liang Y et al (2017) Synthesis of novel β-cyclodextrin functionalized S, N codoped carbon dots for selective detection of testosterone. Biosens Bioelectron 98:195–201. https://doi.org/10.1016/j.bios.2017.06.056
Yang W, Ni J, Luo F et al (2017) Cationic carbon dots for modification-free detection of Hyaluronidase via an electrostatic-controlled Ratiometric fluorescence assay. Anal Chem 89:8384–8390. https://doi.org/10.1021/acs.analchem.7b01705
Devi P, Kaur G, Thakur A et al (2017) Waste derivitized blue luminescent carbon quantum dots for selenite sensing in water. Talanta 170:49–55. https://doi.org/10.1016/j.talanta.2017.03.069
Li Z, Zhang J, Li Y et al (2018) Carbon dots based photoelectrochemical sensors for ultrasensitive detection of glutathione and its applications in probing of myocardial infarction. Biosens Bioelectron 99:251–258. https://doi.org/10.1016/j.bios.2017.07.065
Hou J, Li H, Wang L et al (2016) Rapid microwave-assisted synthesis of molecularly imprinted polymers on carbon quantum dots for fluorescent sensing of tetracycline in milk. Talanta 146:34–40. https://doi.org/10.1016/j.talanta.2015.08.024
Li H, Kang Z, Liu Y, Lee ST (2012) Carbon nanodots: synthesis, properties and applications. J Mater Chem 22:24230. https://doi.org/10.1039/c2jm34690g
Lim SY, Shen W, Gao Z (2015) Carbon quantum dots and their applications. Chem Soc Rev 44:362–381. https://doi.org/10.1039/C4CS00269E
Han T, Yan T, Li Y et al (2015) Eco-friendly synthesis of electrochemiluminescent nitrogen-doped carbon quantum dots from diethylene triamine pentacetate and their application for protein detection. Carbon N Y 91:144–152. https://doi.org/10.1016/j.carbon.2015.04.053
Wang K, Guan F, Li H et al (2015) One-step synthesis of carbon nanodots for sensitive detection of cephalexin. RSC Adv 5:20511–20515. https://doi.org/10.1039/C4RA15433A
Li X, Zhang S, S a K et al (2015) Engineering surface states of carbon dots to achieve controllable luminescence for solid-luminescent composites and sensitive Be2+ detection. Sci Rep 4:4976. https://doi.org/10.1038/srep04976
Wang K, Wang X, Li M et al (2016) Chemiluminescence of O-doped carbon Nanodots prepared in acidic and alkaline conditions. J Biomater Tissue Eng 6:35–41. https://doi.org/10.1166/jbt.2016.1411
Yang M, Li H, Liu J et al (2014) Convenient and sensitive detection of norfloxacin with fluorescent carbon dots. J Mater Chem B 2:7964–7970. https://doi.org/10.1039/C4TB01385A
Niu J, Gao H (2014) Synthesis and drug detection performance of nitrogen-doped carbon dots. J Lumin 149:159–162. https://doi.org/10.1016/j.jlumin.2014.01.026
Acknowledgements
This work was supported by grant No. 1508RJZA078 of the Natural Science Foundation of Gansu, the hongliu young teacher cultivate project of Lanzhou University of Technology (Q201211) and the Doctoral research start-funded projects of Lanzhou University of Technology.
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Wang, K., Ji, Q., Xu, J. et al. Highly Sensitive and Selective Detection of Amoxicillin Using Carbon Quantum Dots Derived from Beet. J Fluoresc 28, 759–765 (2018). https://doi.org/10.1007/s10895-018-2237-0
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DOI: https://doi.org/10.1007/s10895-018-2237-0