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Quantum Dots (QDs) Based Fluorescent Sensor for the Selective Determination of Nimesulide

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Abstract

Fluorescent PET (Photoinduced Electron Transfer) has been of particular growth in recent times. A novel PET based fluorescent sensor using unmodified CdSe quantum dots (QDs) has been developed for the trace determination of Nimesulide (NIM). The sensor is based on the selective fluorescence quenching of quantum dots by NIM in presence of other NSAIDs and is found that intensity of quenching is linearly related to NIM concentration in the range 8.2 × 10−7 – 4.01 × 10−5 M. The mechanism of interaction is discussed. Finally, the potential application of the proposed method for the trace determination of NIM in pharmaceutical formulation is demonstrated.

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Acknowledgment

The authors would like to express their gratitude to Council of Scientific and Industrial Research (CSIR), Inter University Centre for Nano materials and Devices (IUCND) and University Grants Commission (UGC), for the award of research fellowship.

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Authors and Affiliations

  1. Department of Applied Chemistry, Cochin University of Science and Technology, Kochi, 682 022, India

    Divya Thomas, Laina Lonappan, Leena Rajith, Soumya T. Cyriac & Krishnapillai Girish Kumar

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  1. Divya Thomas
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  2. Laina Lonappan
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  3. Leena Rajith
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  4. Soumya T. Cyriac
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  5. Krishnapillai Girish Kumar
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Correspondence to Krishnapillai Girish Kumar.

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Thomas, D., Lonappan, L., Rajith, L. et al. Quantum Dots (QDs) Based Fluorescent Sensor for the Selective Determination of Nimesulide. J Fluoresc 23, 473–478 (2013). https://doi.org/10.1007/s10895-013-1170-5

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  • DOI: https://doi.org/10.1007/s10895-013-1170-5

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