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Active Immunological Profile Is Associated with Systemic Sjögren’s Syndrome

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Abstract

Background

The aim of this paper was to study the evolution of primary Sjögren’s syndrome (pSS) immunological profile, its impact on pSS activity and long-term evolution in a bicentric cohort of French patients with pSS (n = 445, mean age 53.6 ± 14 years, mean follow-up 76.1 ± 51 months).

Methods

This is a retrospective cohort study.

Results

Two hundred twelve patients were Sjögren’s syndrome A (SSA) positive, and 131 were both SSA and Sjögren’s syndrome B (SSB) positive. Sixty-eight patients (15%) had cryoglobulinemia. Active systemic profile (i.e., hypergammaglobulinemia, rheumatoid factor (RF), and anti-Sjögren’s syndrome A (anti-SSA), anti-Sjögren’s syndrome B (anti-SSB) positivity), associated with multisystemic involvement, leads to an increased utilization of corticosteroid and hydroxychloroquine. Multivariate analysis pointed out independent statistical association between hypergammaglobulinemia, anti-SSA, anti-SSB, and RF. Cryoglobulinemia is associated with multi-systemic involvement, lymphoma, and pSS-related death.

Conclusion

The subset of patients with active immunological profile is characterized by systemic complications leading to immunosuppressive drug utilization and polyclonal B-cell activation profile.

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Acknowledgments

We thank Ms Lisa Mouche for the English correction of this manuscript.

Disclosure Statement

The authors have declared no conflicts of interest.

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Authors and Affiliations

  1. Department of Internal Medicine, Limoges University Hospital, Limoges, France

    Clothilde Martel, Guillaume Gondran, Sylvain Palat, Kim Ly, Veronique Loustaud-Ratti, Holly Bezanahary, Elisabeth Vidal & Anne Laure Fauchais

  2. Department of Immunology-EA3842, Limoges University Hospital, Limoges, France

    Clothilde Martel, Fabrice Lalloué, Marie Odile Jauberteau & Anne Laure Fauchais

  3. Department of Internal Medicine, Lille University Hospital, Lille, France

    David Launay, Marc Lambert, Eric Hachulla & Pierre Yves Hatron

  4. Department of Internal Medicine and EA3842-Immunology, Limoges University Hospital, 87042, Limoges, France

    Anne Laure Fauchais

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  1. Clothilde Martel
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Correspondence to Anne Laure Fauchais.

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Martel, C., Gondran, G., Launay, D. et al. Active Immunological Profile Is Associated with Systemic Sjögren’s Syndrome. J Clin Immunol 31, 840–847 (2011). https://doi.org/10.1007/s10875-011-9553-3

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  • DOI: https://doi.org/10.1007/s10875-011-9553-3

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