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NRAMP1 (SLC11A1) Variants: Genetic Susceptibility to Multiple Sclerosis

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Abstract

Objectives

Multiple sclerosis (MS) is an inflammatory, autoimmune demyelinating disease of the central nervous system. Human Natural Resistance Associated Macrophage Protein 1 (NRAMP1) gene polymorphisms have been implicated in the immune mediated diseases susceptibility. This study aimed to investigate the plausible association between NRAMP1 gene and MS susceptibility.

Methods

We analyzed (GT)n, INT4, 3′UTR and D543N polymorphisms of NRAMP1 gene in 100 MS patients and 104 healthy subjects by using amplification refractory mutation system-polymerase chain reaction and sequence analysis.

Results

No significant association was found between (GT)n, INT4, 3′UTR and D543N polymorphisms and MS. There was also no correlation between NRAMP1 polymorphisms and MS clinical forms.

Conclusions

Our findings suggest that NRAMP1 polymorphisms do not play a role in MS susceptibility and clinical finding of MS in Turkish patients.

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Acknowledgments

This work was supported by Gaziosmanpasa University Scientific Research Projects Fund. Project numbers: 2008/14. The authors especially thank Selime Tabanlıoglu for editing the article.

Disclosures

The authors of this article declare no conflict of interest.

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Authors and Affiliations

  1. Department of Medical Biology, Medical Faculty, Gaziosmanpasa University, 60100, Tokat, Turkey

    Omer Ates & Nihan Bozkurt

  2. Department of Neurology, Medical Faculty, Gaziosmanpasa University, 60100, Tokat, Turkey

    Semiha Kurt & Hatice Karaer

Authors
  1. Omer Ates
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  2. Semiha Kurt
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  3. Nihan Bozkurt
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  4. Hatice Karaer
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Correspondence to Omer Ates.

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Ates, O., Kurt, S., Bozkurt, N. et al. NRAMP1 (SLC11A1) Variants: Genetic Susceptibility to Multiple Sclerosis. J Clin Immunol 30, 583–586 (2010). https://doi.org/10.1007/s10875-010-9422-5

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  • DOI: https://doi.org/10.1007/s10875-010-9422-5

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