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The CCR5 (−2135C/T) Polymorphism may be Associated with the Development of Kawasaki Disease in Korean Children

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Abstract

Background

Kawasaki disease (KD) is an acute vasculitis syndrome of unknown etiology that frequently affects small to medium size arteries. C-C chemokine receptor 5 (CCR5) is a chemokine receptor that binds C-C chemokines. This study investigated the association of the CCR5 (−2135C/T) polymorphism with KD in Korean children.

Methods

The study population consisted 189 Korean children with KD and 194 Korean children with congenital heart disease (CHD). CCR5 (−2135C/T) polymorphism genotypes were determined using the single-base extension method.

Results

The allele frequencies of the CCR5 (−2135C/T) polymorphism differed significantly between CHD children and KD children (−2135T/T, 16.75% vs. 30.05%, aOR 2.14, 95% CI 1.31–3.51). The tested laboratory parameters differed significantly between the KD and CHD groups. The development of coronary artery aneurysm in KD patients was not associated with the CCR5 polymorphism.

Conclusions

Our findings suggest that the T allele at the CCR5 (−2135C/T) polymorphism might be associated with the development of KD in Korean children but does not appear to be associated with the development of coronary artery aneurysm.

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Acknowledgments

This study was sponsored by grants from the Korean Ministry for Health, Welfare and Family Affairs (01-PJ10-PG6-01GN15-0001).

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Authors and Affiliations

  1. Department of Pediatrics, Asan Medical Center, College of Medicine, Ulsan University, Seoul, South Korea

    Won Kyoung Jhang, Mi-Jin Kang, Hyun-Seung Jin, Jinho Yu, Byoung-ju Kim, Bong Seong Kim, Jong-Keuk Lee, Han-Wook Yoo, In Sook Park & Soo-Jong Hong

  2. Laboratory Medicine, Asan Medical Center, College of Medicine, Ulsan University, Seoul, South Korea

    Eul-Ju Seo

  3. Department of Pediatrics, College of Medicine, Ewha Womans University Hospital, Seoul, South Korea

    Young Mi Hong

  4. Department of Pediatrics, Asan Medical Center, 388-1 Pungnap-2dong, Songpa-gu, Seoul, 138-736, South Korea

    Soo-Jong Hong

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  1. Won Kyoung Jhang
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Correspondence to Soo-Jong Hong.

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Jhang, W.K., Kang, MJ., Jin, HS. et al. The CCR5 (−2135C/T) Polymorphism may be Associated with the Development of Kawasaki Disease in Korean Children. J Clin Immunol 29, 22–28 (2009). https://doi.org/10.1007/s10875-008-9218-z

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  • DOI: https://doi.org/10.1007/s10875-008-9218-z

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