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Transformation of neuronal modes associated with low-Mg2 + /high-K +  conditions in an in vitro model of epilepsy

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Abstract

Nonparametric system modeling constitutes a robust method for the analysis of physiological systems as it can be used to identify nonlinear dynamic input–output relationships and facilitate their description. First- and second-order kernels of hippocampal CA3 pyramidal neurons in an in vitro slice preparation were computed using the Volterra–Wiener approach to investigate system changes associated with epileptogenic low-magnesium/high-potassium (low-Mg2 + /high-K + ) conditions. The principal dynamic modes (PDMs) of neurons were calculated from the first- and second-order kernel estimates in order to characterize changes in neural coding functionality. From our analysis, an increase in nonlinear properties was observed in kernels under low-Mg2 + /high-K + . Furthermore, the PDMs revealed that the sampled hippocampal CA3 neurons were primarily of integrating character and that the contribution of a differentiating mode component was enhanced under low-Mg2 + /high-K + .

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Authors and Affiliations

  1. Institute of Biomaterials and Biomedical Engineering, University of Toronto, 164 College Street, Toronto, ON, M5S 3G9, Canada

    Eunji E. Kang, Osbert C. Zalay, Marija Cotic & Berj L. Bardakjian

  2. Edward S. Rogers Sr. Department of Electrical and Computer Engineering, University of Toronto, 10 King’s College Road, Toronto, ON, M5S 3G4, Canada

    Eunji E. Kang & Berj L. Bardakjian

  3. Division of Fundamental Neurobiology, Toronto Western Research Institute, 399 Bathurst Street, Toronto, ON, M5T 2S8, Canada

    Eunji E. Kang, Marija Cotic & Peter L. Carlen

  4. Department of Physiology, University of Toronto, 1 King’s College Circle, Toronto, ON, M5S 1A8, Canada

    Peter L. Carlen

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  1. Eunji E. Kang
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  2. Osbert C. Zalay
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  3. Marija Cotic
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  4. Peter L. Carlen
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  5. Berj L. Bardakjian
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Correspondence to Berj L. Bardakjian.

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Kang, E.E., Zalay, O.C., Cotic, M. et al. Transformation of neuronal modes associated with low-Mg2 + /high-K +  conditions in an in vitro model of epilepsy. J Biol Phys 36, 95–107 (2010). https://doi.org/10.1007/s10867-009-9144-1

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  • DOI: https://doi.org/10.1007/s10867-009-9144-1

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