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Tantalum-incorporated hydroxyapatite coating on titanium implants: its mechanical and in vitro osteogenic properties

  • Biomaterials Synthesis and Characterization
  • Original Research
  • Published:
Journal of Materials Science: Materials in Medicine Aims and scope Submit manuscript

Abstract

Objective

The fabrication of bioactive coatings on metallic implants to enhance osseointegration has become a topic of general interest in orthopedics and dentistry. Hydroxyapatite (HA) coating has been shown to induce bone formation and promote bone-implant integration. Unfortunately, poor mechanical performance has hindered this from becoming a favorable coating material. The majority of present studies have focused in incorporating different elements into HA coatings to improve mechanical properties. In recent years, tantalum (Ta) has received increasing attention due to its excellent biocompatibility and corrosion resistance. The aim of on the present study was to investigate the fabrication and biological performance of Ta-incorporated HA coatings.

Methods

Ta-incorporated HA coatings were fabricated using the plasma spray technique on a titanium substrate, and the surface characteristics and mechanical properties were examined. In addition, the effects of Ta-incorporated HA coatings on the biological behavior of mesenchymal stem cells (BMSCs) were investigated.

Results

Ta-incorporated HA coatings with microporous structure had higher roughness and wettability. In addition, the bonding strength of Ta/HA coatings with the substrate was substantially superior to HA coatings. Furthermore, Ta-incorporated HA coatings not only facilitated initial cell adhesion and faster proliferation, but also promoted the osteogenic differentiation of BMSCs.

Conclusion

These results indicate that the incorporation of Ta could improve mechanical performance and increase the osteogenic activity of HA coatings. The Ta-incorporated HA coating fabricated by plasma spraying is expected to be a promising bio-coating material for metallic implants.

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Acknowledgements

This study was financially supported by National High Technology Research and Development Program of China (No. 2015AA033502), Natural Science Foundation of Beijing (No. 7182125), National Natural Science Foundation of China (No. 81271180) and Natural Science Foundation of Beijing (No. 2017000062586G232).

Author information

Author notes

  1. These authors contributed equally: Rong-Jian Lu, Xing Wang

Authors and Affiliations

  1. Department of Stomatology, the Fifth Medical Center, Chinese PLA General Hospital, 100071, Beijing, China

    Rong-Jian Lu

  2. Department of Stomatology, the First Medical Center, Chinese PLA General Hospital, 100853, Beijing, China

    Rong-Jian Lu, Hui-Xia He, Ling-Ling E, Gui-Lan Zhang, Chuan-Jie Li & Hong-Chen Liu

  3. Shanxi Medical University School and Hospital of Stomatology, 030001, Taiyuan, China

    Xing Wang

  4. School of Materials Science and Technology, South China University of Technology, 510641, Guangzhou, China

    Ying Li & Cheng-Yun Ning

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  1. Rong-Jian Lu
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Lu, RJ., Wang, X., He, HX. et al. Tantalum-incorporated hydroxyapatite coating on titanium implants: its mechanical and in vitro osteogenic properties. J Mater Sci: Mater Med 30, 111 (2019). https://doi.org/10.1007/s10856-019-6308-9

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