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Novel resin-based dental material with anti-biofilm activity and improved mechanical property by incorporating hydrophilic cationic copolymer functionalized nanodiamond

  • Biomaterials Synthesis and Characterization
  • Original Research
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Abstract

There is an increasing clinical need to design dental restorative materials that combine excellent mechanical property and anti-biofilm activity. In the current study, photocurable polycation functionalized nanodiamond (QND) was synthesized and proposed as novel filler for dental resins. By reason of increased repulsive force between nanoparticles and enhanced compatibility with resin matrix, QND dispersed uniformly in reinforced resins, which would help to transfer stress and deformation from the matrix to fillers more efficiently, resulting in a significant improvement in mechanical properties. Notably, the Vickers’s hardness, flexural strength and flexural modulus of resins containing 1.0 wt% QND were 44.5, 36.1 and 41.3% higher than that of control, respectively. The antibacterial activity against Streptococcus mutans (S. mutans) showed that QND-incorporated resins produced anti-adhesive property due to their hydrophilic surfaces and could suppress bacterial growth as a result of the contact-killing effect of embedded nanocomposites. As the synergistic effect of anti-adhesive and bactericidal performance, resins loading 1.0~1.5 wt% QNDs displayed excellent anti-biofilm activity. Meanwhile, the results of macrophage cytotoxicity showed that the proliferation of RAW 264.7 cells remained 84.3%, even at a concentration of 1.0 wt% QNDs after 7-day incubation. Therefore, the QND-containing dental resin with the combination of high mechanical property, bacteria-repellent capability and antibacterial performance holds great potential as a restorative material based on this scheme.

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Acknowledgements

This research was supported by the Research Fund from the Natural Science Foundation of China (No. 81460107).

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Authors and Affiliations

  1. College of Chemical Engineering, Nanjing University of Science and Technology, Nanjing, 210094, China

    Weiwei Cao, Xi Wang, Qiang Li, Peili Li, Lina Wang, Zhiwen Ye & Xiaodong Xing

  2. Department of Stomatology, Kunming General Hospital of Chengdu Military Command, Kunming, 650032, China

    Yuhong Xiao

  3. Center for Dental Research, School of Dentistry, Loma Linda University, Loma Linda, CA, 92350, USA

    Yuhong Xiao

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  1. Weiwei Cao
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  2. Yu Zhang
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Cao, W., Zhang, Y., Wang, X. et al. Novel resin-based dental material with anti-biofilm activity and improved mechanical property by incorporating hydrophilic cationic copolymer functionalized nanodiamond. J Mater Sci: Mater Med 29, 162 (2018). https://doi.org/10.1007/s10856-018-6172-z

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