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Self-assembled polyelectrolyte complexes films as efficient compression coating layers for controlled-releasing tablets

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Abstract

Currently, polysaccharide-based hydrogels are widely studied macromolecular networks to modify drug dissolution from controlled-releasing matrix tablets. Among them, polyelectrolyte complexes (PEC) films consisted of chitosan (CS) and sodium alginate (SA) could be obtained via spontaneously assembling under physiological gastrointestinal environment. Here, we utilized these self-assembled PEC films as an efficient coating materials to develop controlled-released matrix tablets through compression coating process, with paracetamol (APAP) as model drug. The constitutive and morphology characteristic studies on these PEC films illustrated that the mixture of CS and SA with the weight ratio of 1:1 would be an promising outer layer for compression-coating tablets. In addition, the in vitro drug releasing behavior experiments demonstrated that the optimized compression coating tablets displayed satisfied zero-order drug releasing profits. Furthermore, the in vivo pharmacokinetic studies of these APAP loaded compression-coated tablets in New Zealand rabbits gave that the Tmax (12.32 ± 1.05 h) was significantly prolonged (p < 0.01), compared to that (0.89 ± 0.26 h) of common APAP tablets (Jinfuning®) after oral administration. These studies suggest that the compression-coated tablets with self-assembled PEC film as coating outer layer may be a promising strategy for peroral controlled release delivery system of water soluble drugs.

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Acknowledgements

This work was financially supported by the National Natural Science Foundation of China (No. 81402859).

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Authors and Affiliations

  1. Key Laboratory of Modern Chinese Medicines, China Pharmaceutical University, Nanjing, 210009, People’s Republic of China

    Wenyan Li, Mengmeng Huo, Arka Sen Chaudhuri, Chen Yang, Dazhong Cao, Zhenghong Wu & Xiaole Qi

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  1. Wenyan Li
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Correspondence to Zhenghong Wu or Xiaole Qi.

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Li, W., Huo, M., Sen Chaudhuri, A. et al. Self-assembled polyelectrolyte complexes films as efficient compression coating layers for controlled-releasing tablets. J Mater Sci: Mater Med 28, 67 (2017). https://doi.org/10.1007/s10856-017-5886-7

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