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Extended pulsated drug release from PLGA-based minirods

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Abstract

The kinetics of degradation and sustained cancer drugs (paclitaxel (PT) and prodigiosin (PG)) release are presented for minirods (each with diameter of ~5 and ~6 mm thick). Drug release and degradation mechanisms were studied from solvent-casted cancer drug-based minirods under in vitro conditions in phosphate buffer solution (PBS) at a pH of 7.4. The immersed minirods were mechanically agitated at 60 revolutions per minute (rpm) under incubation at 37 °C throughout the period of the study. The kinetics of drug release was studied using ultraviolet visible spectrometry (UV-Vis). This was used to determine the amount of drug released at 535 nm for poly(lactic-co-glycolic acid) loaded with prodigiosin (PLGA-PG) samples, and at 210 nm, for paclitaxel-loaded samples (PLGA-PT). The degradation characteristics of PLGA-PG and PLGA-PT are elucidated using optical microscope as well as scanning electron microscope (SEM). Statistical analysis of drug release and degradation mechanisms of PLGA-based minirods were performed. The implications of the results are discussed for potential applications in implantable/degradable structures for multi-pulse cancer drug delivery.

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References

  1. Alwan A. Global status report on noncommunicable diseases in 2010. Geneva: World Health Organization; 2011. p. 164

    Google Scholar 

  2. Ferlay J, Shin HR, Bray F, Forman D, Mathers CD, Parkin DM. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J of Cancer. 2010;127:2893–917.

    Article  Google Scholar 

  3. Mathers DC, Loncar D. Updated projections of global mortality and burden of disease, 2002–2030; data sources, methods and results. Geneva, Switzerland: World Health Organization; 2005. p. 6.

  4. Borgstede JP, Bagrosky BM. Early diagnosis and treatment of cancer series: breast cancer: screening of high-risk patients. Philadelphia: Saunders Elsevier; 2011.

    Google Scholar 

  5. Pisano ED, Gatsonis C, Hendrick E, Yaffe M, Baum JK, Acharyya S, Conant EF, Fajardo LL, Bassett L, D’Orsi C, Jong R, Rebner M. Diagnostic performance of digital versus film mammography for breast-cancer screening. N Engl J Med. 2005;353:1773–83.

    Article  Google Scholar 

  6. Saslow D, Boetes C, Burke W, Harms S, Leach MO, Lehman CD, Morris E, Pisano E, Schnall M, Sener S, Smith RA, Warner E, Yaffe M, Adrews KS, Russell CA. American cancer society guidelines for breast screening with MRI as an adjunct to mammography. CA Cancer J Clin. 2007;57:75–89.

    Article  Google Scholar 

  7. Smith RA, Saslow D, Sawyer KA, Burke W, Costanza ME, Evans WP III, Foster RS, Hendrick E, Eyre HJ, Sener S. American cancer society guidelines for breast cancer screening. CA Cancer J Clin. 2003;53:141–69.

    Article  Google Scholar 

  8. Breast Cancer Signs & Symptoms. In: Early symptoms. What health, healthy living for everybody. 2016. http://www.whathealth.com/breastcancer/symptoms.html. Accessed 15 Dec 2016.

  9. David N, Mark WD. The development and testing of a new temperature-sensitive drug delivery system for the treatment of solid tumors. Adv Drug Deliv Rev. 2001;53:285–305.

    Article  Google Scholar 

  10. Hildebrandt B, Wustin P, Ceelen WP. Peritoneal carcinomatosis: a multidisciplinary approach. New York, NY: Springer; 2007.

    Google Scholar 

  11. Oni Y, Theriault C, Hoek AV, Soboyejo WO. Effects of temperature on diffusion from PNIPA-based gels in a BioMEMS device for localized chemotherapy and hyperthermia. Mater Sci Eng C. 2011;31:67–76.

    Article  Google Scholar 

  12. Oni Y, Soboyejo WO. Swelling and diffusion of pnipa-based gels for localized chemotherapy and hyperthermia. Mater Sci Eng C. 2012;32:24–30.

    Article  Google Scholar 

  13. Kavanagh BD, Timmerman RD. Stereotactic body radiation therapy. 1st ed. Philadelphia: Lippincott Williams & Wilkins; 2004.

    Google Scholar 

  14. Del Regato JA. Radiological oncologists: the unfolding of a medical specialty. Reston (VA): Radiology Centennial Inc., University of Michigan, USA; 1993;268: 167–76.

  15. Xu M, Qian J, Liu X, Liu T, Wang H. Stimuli-responsive pegylated prodrugs for targeted doxorubicin delivery. Mater Sci Eng C. 2015;50:341–47.

    Article  Google Scholar 

  16. Danyuo Y, Ani CJ, Obayemi JD, Dozie-Nwachukwu S, Odusanya OS, Oni Y, Anuku N, Malatesta K, Soboyejo WO. Advanced Materials for Sustainable Development. In: Soboyejo W, Odusanya S, Kana Z, Anukwu N, Malatesta K, Dauda M, editors. Prodigiosin release from an implantable biomedical device: effect on cell viability. Switzerland: Trans Tech Publications; 2016. p. 3–18.

  17. Uhrich KE, Cannizzaro SM, Langer RS, Shakesheff KM. Polymeric systems for controlled drug release. Chem Rev. 1999;99:3181–98.

    Article  Google Scholar 

  18. Danyuo Y, Obayemi JD, Dozie-Nwachukwu S, Ani CJ, Odusanya OS, Oni Y, Anuku N, Malatesta K, Soboyejo WO. Prodigiosin release from an implantable biomedical device: kinetics of localized cancer drug release. J Mater Sci Eng C. 2014;42(1):734–45.

    Article  Google Scholar 

  19. Makadia HK, Siege SJ. Poly lactic-co-glycolic acid (PLGA) as biodegradable controlled drug delivery carrier. Polymers (Basel). 2011;3(3):1377–97.

    Article  Google Scholar 

  20. Allison SD. Effect of structural relaxation on the preparation and drug release behavior of poly(lactic-co-glycolic)acid microparticle drug delivery systems. J Pharm Sci. 2008;97:2022–35.

    Article  Google Scholar 

  21. Mundargi R, Babu V, Rangaswamy V, Patel P, Aminabhavi T. Nano/micro technologies for delivering macromolecular therapeutics using poly(D,L-lactide-co-glycolide) and its derivatives. J Cont Rel. 2008;125:193–209.

    Article  Google Scholar 

  22. Mohamed F, van der Walle CF. Engineering biodegradable polyester particles with specific drug targeting and drug release properties. J Pharm Sci. 2008;97:71–87.

    Article  Google Scholar 

  23. Metters AT, Bowman CN. A statistical kinetic model for the bulk degradation of PLA-b-PEG-b-PLA hydrogel networks; incorporating network non-idealities. J Phys Chem B. 2001;104:8069–76.

    Article  Google Scholar 

  24. Obayemi JD, Danyuo Y, Dozie-Nwachukwu S, Odusanya OS, Anuku N, Malatesta K, Yu W, Uhrich KE, Soboyejo WO. PLGA-based microparticles loaded with bacterial-synthesized prodigiosin for anticancer drug release: effects of particle size on drug release kinetics and cell viability. Mater Sci Eng C. 2016;66:51–65.

    Article  Google Scholar 

  25. Behravesh E, Yasko AW, Engel PS, Mikos AG. Synthetic biodegradable polymers for orthopaedic applications. Clin Orthop Relat Res. 1999;367:118–25.

    Article  Google Scholar 

  26. Middleton E Jr., Kandaswami C, Theoharide TC. The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease and cancer. Pharmacol Rev. 2000;52(4):673–751.

    Google Scholar 

  27. Park TG. Degradation of poly (D,L-lactic acid) microspheres: effect of molecular weight. J Control Release. 1994;30:161–73.

    Article  Google Scholar 

  28. Metzmacher I, Radu F, Bause M, Knabner P, Friess W. A model describing the effect of enzymatic degradation on drug release from collagen minirods. Eur J Pharm Biopharm. 2007;67(2):349–60.

    Article  Google Scholar 

  29. Danyuo Y, Dozie-Nwachukwu S, Obayemi JD, Ani CJ, Odusanya OS, Oni Y, Anuku N, Malatesta K, Soboyejo WO. Swelling of poly(N-isopropyl acrylamide) (PNIPA)-based hydrogels with bacterial-synthesized prodigiosin for localized cancer drug delivery. Mater Sci Engr C. 2016;59:19–29.

    Article  Google Scholar 

  30. Flanagan RJ, Taylor AA, Watson ID, Whelpton R. Fundamentals of analytical toxicology. Newyork, USA: Wiley and Sons; 2007. p. 1–486.

  31. Pathiraja AG, Raju A. Biodegradable synthetic polymers for tissue engineering. Eur Cell Mater. 2003;6:1–16.

    Article  Google Scholar 

  32. Koleske JV. Blends containing poly(∈-caprolactone) and related polymers. In: Paul R, Newman S, editors. Polymer Blends. New York, NY: Academic; 1978. p. 369–89.

    Chapter  Google Scholar 

  33. Peppas AN. Analysis of fickian and non-fickian drug release from polymers. Pharm Acta Helv. 1985;60(4):110–11.

    Google Scholar 

  34. Danyuo Y, Obayemi JD, Dozie-Nwachukwu S, Ani CJ, Odusanya OS, Oni Y, Anuku N, Malatesta K, Soboyejo WO. Prodigiosin release from an implantable biomedical device: kinetics of localized cancer drug release. Mater Sci Eng C. 2014;42(1):734–45.

    Article  Google Scholar 

  35. Ogunnaike BA. Random phenomena, fundamentals of probability & statistics for engineers. Newark: University of Delaware; 2009.

    Book  Google Scholar 

  36. McDonald JH. Handbook of biological statistics. 3rd ed. Maryland: Sparky House Publishing; 2014.

    Google Scholar 

  37. Thomas CDL, Feik SA and Clement JG. Increase in pore area, and not pore density, is the main determinant in the development of porosity in human cortical bone. J Anat. 2006;209:219–30.

  38. Obayemi JD, Danyuo Y, Dozie-Nwachukwu S, Odusanya OS, Anuku N, Malatesta K, Yu W, Uhrich KE, Soboyejo WO. PLGA-based microparticles loaded with bacterial-synthesized prodigiosin for anticancer drug release: effects of particle size on drug release kinetics and cell viability. Mater Sci Eng C. 2016;66:51–65.

    Article  Google Scholar 

  39. Tamagawa H, Popovic S, Taya M. Pores and diffusion characteristics of porous gels. Polymer. 2000;41:7201–7.

    Article  Google Scholar 

  40. Bae SE, Sona JS, Parka K, Han DK. Fabrication of covered porous PLGA microspheres using hydrogen peroxide for controlled drug delivery and regenerative medicine. J Control Release. 2009;133(1):37–43.

    Article  Google Scholar 

  41. Chen J, Lee J-W, Hernandez de Gatica NL, Burkhardt CA, Hercules DM, Gardella JA Jr. Time-of-flight secondary ion mass spectrometry studies of hydrolytic degradation kinetics at the surface of poly(glycolic acid). Macromolecules. 2000;33:4726–32.

    Article  Google Scholar 

  42. Klose D, Siepmann F. PLGA-based drug delivery systems: importance of the type of drug and device geometry. Int J Pharm. 2008;354:95–103.

    Article  Google Scholar 

  43. Engineer C, Parikh J, Raval A. Review on hydrolytic degradation behavior of biodegradable polymers from controlled drug delivery system. Trends Biomater Artif Organs. 2011;25(2):79–85.

    Google Scholar 

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Acknowledgements

The authors are very grateful to the World Bank African Centres of Excellent Project (Pan-African Materials Institute (PAMI) with grant No. P126974), the African Capacity Building Foundation with Grant No. 292, Princeton University School of Engineering and Applied Sciences (SEAS) and the Worcester Polytechnic Institute for financial support. The authors are also grateful to the Nelson Mandela Institute (NMI) and the African University of Science and Technology (AUST) for the scholarships given to the students. Appreciation is also extended to Prof. Eric Garfunkel and Dr. Adeoye Soyemi for useful technical discussions.

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Authors and Affiliations

  1. Department of Materials Science and Engineering, African University of Science and Technology (AUST), Abuja, Federal Capital Territory, Nigeria

    Y. Danyuo, J. D. Obayemi, S. Dozie-Nwachukwu & W. O. Soboyejo

  2. Department of Materials Science and Engineering, Kwara State University, Ilorin, Nigeria

    Y. Danyuo & M. G. Zebaze Kana

  3. Biotechnology and Genetic Engineering Advanced Laboratory, Sheda Science and Technology Complex (SHESTCO), Abuja, Federal Capital Territory, Nigeria

    O. E. Oberaifo, S. Dozie-Nwachukwu & O. S. Odusanya

  4. Department of Mechanical and Aerospace Engineering 41 Olden Street, Princeton University, Princeton, NJ, 08544, USA

    J. D. Obayemi & W. O. Soboyejo

  5. Department of Theoretical Physics, African University of Science and Technology (AUST), Abuja, Federal Capital Territory, Nigeria

    C. J. Ani

  6. Department of Physics, Salem University, Lokoja-Ajaokuta Road, Lokoja, Kogi, Nigeria

    C. J. Ani

  7. Princeton Institute for the Science and Technology of Materials (PRISM), Princeton University, 70 Prospect Street, Princeton, NJ, 08544, USA

    K. Malatesta & W. O. Soboyejo

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  1. Y. Danyuo
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  2. O. E. Oberaifo
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  3. J. D. Obayemi
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  6. O. S. Odusanya
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  7. M. G. Zebaze Kana
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  8. K. Malatesta
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  9. W. O. Soboyejo
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Correspondence to W. O. Soboyejo.

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Danyuo, Y., E. Oberaifo, O., Obayemi, J.D. et al. Extended pulsated drug release from PLGA-based minirods. J Mater Sci: Mater Med 28, 61 (2017). https://doi.org/10.1007/s10856-017-5866-y

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