Abstract
Beyond promoting hard tissue repairing, bioactive glasses (BGs) have also been proved to be beneficial for wound healing. Nano-scale BGs prepared by sol-gel method were found to have a better performance as they have a larger specific surface area. In this work, bioactive nanoparticles (nBPs) with mean diameter of 12 nm (BP-12) instead of conventional BGs were mixed with gelatin to form an easy-to-use hydrogel as a dressing for skin wound. It was found that the composite of BP-12 and gelatin could form a hydrogel (BP-12/Gel) under 25 °C, which showed pronounced thixotropy at a practically accessible shear rate, therefore become easy to be used for wound cover. In vitro, the composite hydrogel of BP-12 and gelatin had good biocompatibility with the fibroblast cells. In vivo, rapid cutaneous-tissue regeneration and tissue-structure formation within 7 days was observed in the wound-healing experiment performed in rats. This hydrogel is thus a promising easy-to-use wound dressing material.
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Acknowledgements
This work was supported by MOST (Project No. 2012CB933200, 2013DFG52300) and NSFC (Project No. 21474122, 51173193, 81202931).
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Wang, C., Zhu, F., Cui, Y. et al. An easy-to-use wound dressing gelatin-bioactive nanoparticle gel and its preliminary in vivo study. J Mater Sci: Mater Med 28, 10 (2017). https://doi.org/10.1007/s10856-016-5823-1
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DOI: https://doi.org/10.1007/s10856-016-5823-1