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Effects of bevacizumab loaded PEG-PCL-PEG hydrogel intracameral application on intraocular pressure after glaucoma filtration surgery

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Abstract

PEG-PCL-PEG (PECE) hydrogel for intracameral injection as a sustained delivery system can get a stable release of the medication and achieve an effective local concentration. The injectable PECE hydrogel is thermosensitive nano-material which is flowing sol at low temperature and can shift to nonflowing gel at body temperature. This study evaluated the intracameral injection of bevacizumab combined with a PECE hydrogel drug release system on postoperative scarring and bleb survival after experimental glaucoma filtration surgery. The best result was achieved in the bevacizumab loaded PECE hydrogels group, which presented the lowest IOP values after surgery. And the blebs were significantly more persistent in this group. Histology, Massion trichrome staining and immunohistochemistry further demonstrated that glaucoma filtration surgery in combination with bevacizumab loaded PECE hydrogel resulted in good bleb survival due to scar formation inhibition. In conclusions, this study demonstrated that bevacizumab-loaded PECE hydrogel for intracameral injection as a sustained delivery system provide a great opportunity to increase the therapeutic efficacy of glaucoma filtration surgery.

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Acknowledgments

This work was supported by the National Nature Science Foundation of China (No. 30901658) and International Science & Technology Cooperation Program of China (No. 2013DFG52300). Dr. Ling Yu and Dr. Zhiyong Qian contributed equally and are regarded as Co-Correspondence authors.

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Authors and Affiliations

  1. Department of Ophthalmology, Affiliated Hospital of Luzhou Medical College, Luzhou, 646000, Sichuan Province, China

    Qian Han, Yuqi Wang, Ribo Peng & Ling Yu

  2. Department of Pathology, Affiliated Hospital of Luzhou Medical College, Luzhou, 646000, Sichuan Province, China

    Xiabin Li

  3. School of Public Health of Luzhou Medical College, Luzhou, 646000, Sichuan Province, China

    Ailing Li

  4. State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan Province, China

    Zhiyong Qian

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  1. Qian Han
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Correspondence to Zhiyong Qian or Ling Yu.

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Han, Q., Wang, Y., Li, X. et al. Effects of bevacizumab loaded PEG-PCL-PEG hydrogel intracameral application on intraocular pressure after glaucoma filtration surgery. J Mater Sci: Mater Med 26, 225 (2015). https://doi.org/10.1007/s10856-015-5556-6

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  • DOI: https://doi.org/10.1007/s10856-015-5556-6

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