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Comparison of the effects of Mg–6Zn and titanium on intestinal tract in vivo

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Abstract

To evaluate the ability of Mg–6Zn to replace titanium nails in the reconstruction of the intestinal tract in general surgery, we compared the Mg–6Zn and titanium implants with respect to their effects on rat’s intestinal tract by biochemical, radiological, pathological and immunohistochemical methods. The results indicated that Mg–6Zn implants started to degrade at the third week and disintegrate at the fourth week. No bubbles appeared, which may be associated with intestinal absorption of the Mg–6Zn implants. Pathological analyses (containing liver, kidney and cecum tissues) and biochemical measurements, including serum magnesium, creatinine, blood urea nitrogen, glutamic–pyruvic–transaminase and glutamic–oxaloacetic–transaminase proved that degradation of Mg–6Zn did not harm the important organs, which is an improvement over titanium implants. Immunohistochemical results showed that Mg–6Zn could enhance the expression of transforming growth factor-β1. Mg–6Zn reduced the expression of tumor necrosis factor at different stages. In general, our study demonstrates that the Mg–6Zn alloy had good biocompatibility in vivo and performed better than titanium at promoting healing and reducing inflammation. It may be a promising candidate for stapler pins in intestinal reconstruction.

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Acknowledgments

This work was supported by the National Natural Science Foundation of China (No. 30901422) and Shanghai Jiao Tong University Interdisciplinary (Biomedical Engineering) Research Fund (No. YG2010MS45). Shanghai Jiaotong University School of Medicine Science and Technology Fund (No. 09XJ21005).

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Authors and Affiliations

  1. Shanghai Jiaotong University School of Medicine, 227 South Chongqing Road, Shanghai, 200025, People’s Republic of China

    Jun Yan, Yigang Chen, Zhigang Wang, Kaixing Ai & Qi Zheng

  2. Department of General Surgery, Sixth People’s Hospital, Shanghai Jiao Tong University School of Medicine, 600 Yishan Road, Shanghai, 200233, People’s Republic of China

    Jun Yan, Song Yu, Wencai Qiu, Chengguang Yang, Zhigang Wang, Jianfeng Gong, Kaixing Ai & Qi Zheng

  3. Department of Thyroid Surgery, The First Affiliated Hospital of Zhengzhou University, 1 Jianshe East Road, Zhengzhou, 450052, Henan, People’s Republic of China

    Qingling Yuan

  4. State Key Laboratory of Metal Matrix Composites, School of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai, 200240, People’s Republic of China

    Jianan Li, Shaoxiang Zhang & Xiaonong Zhang

Authors
  1. Jun Yan
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  2. Yigang Chen
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  3. Qingling Yuan
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  4. Song Yu
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  9. Kaixing Ai
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  10. Qi Zheng
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  11. Jianan Li
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  13. Xiaonong Zhang
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Corresponding author

Correspondence to Qi Zheng.

Additional information

Jun Yan and Yigang Chen contributed equally to this work.

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Yan, J., Chen, Y., Yuan, Q. et al. Comparison of the effects of Mg–6Zn and titanium on intestinal tract in vivo. J Mater Sci: Mater Med 24, 1515–1525 (2013). https://doi.org/10.1007/s10856-013-4906-5

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  • DOI: https://doi.org/10.1007/s10856-013-4906-5

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