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Injectable and fast resorbable calcium phosphate cement for body-setting bone grafts

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Abstract

In this work a calcium phosphate (CPC)/polymer blend was developed with the advantage of being moldable and capable of in situ setting to form calcium deficient hydroxyapatite under physiological conditions in an aqueous environment at body temperature. The CPC paste consists in a mix of R cement, glycerol as a liquid phase carrier and a biodegradable hydrogel such as Polyvinyl alcohol, which acts as a binder. Microstructure and mechanical analysis shows that the CPC blend can be used as an injectable implant for low loaded applications and fast adsorption requirements. The storage for commercial distribution was also evaluated and the properties of the materials obtained do not significantly change during storage at −18°C.

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Acknowledgments

This work was supported by the Spanish Ministry of Education and Science, project “Estancias de jovenes doctores extranjeros en universidades publicas y centros de investigacion españoles” 2007–2008. O. Castano also acknowledges the MICINN for the Ramony Cajal contract.

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Authors and Affiliations

  1. Institute for Bioengineering of Catalonia (IBEC), C/Baldiri i Reixach, 4–6, Tower I, 10th floor, 08028, Barcelona, Spain

    I. Rajzer, O. Castaño, E. Engel & J. A. Planell

  2. Networking Research Centre on Bioengineering, Biomaterials and Nanomedicine, CIBER-BBN, Barcelona, Spain

    O. Castaño & J. A. Planell

  3. Department of Polymer Materials, ATH, University of Bielsko-Biala, Institute of Textile Engineering and Polymer Materials, Bielsko-Biała, Poland

    I. Rajzer

  4. Technical University of Catalonia (UPC), Barcelona, Spain

    E. Engel

Authors
  1. I. Rajzer
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  2. O. Castaño
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  3. E. Engel
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  4. J. A. Planell
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Correspondence to O. Castaño.

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Rajzer, I., Castaño, O., Engel, E. et al. Injectable and fast resorbable calcium phosphate cement for body-setting bone grafts. J Mater Sci: Mater Med 21, 2049–2056 (2010). https://doi.org/10.1007/s10856-010-4078-5

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  • DOI: https://doi.org/10.1007/s10856-010-4078-5

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