Abstract
The present investigation comprises the formulation and in vitro evaluation of domperidone loaded transdermal drug delivery system (TDDS) for controlled release. The polymer membranes were prepared using xanthan gum (XG) and sodium alginate (SA) by varying the blends compositions viz., 10:0, 8:2, 6:4, 5:5, 4:6, 2:8, and 0:10 (XG/SA, wt/wt, %). The drug loaded membranes were evaluated for thickness, content uniformity, tensile behaviours, and in vitro drug release studies. Domperidone was found to be compatible with the prepared formulation as revealed by Fourier transform infrared (FTIR) spectroscopy studies. In vitro release studies were carried out in open glass diffusion cell for a period of 8 h and it showed controlled release of drug from the XG/SA matrix. The present study concludes that, the prepared transdermal films can be used to achieve controlled release of drug and improved bioavailability.
Similar content being viewed by others
References
Babar A, Pillai J, Plakogiaannis FM. Release and permeation studies of propranolol hydrochloride from hydrophilic polymeric matrices. Drug Dev Ind Pharm. 1992;18(16):1823–30.
Das MK, Bhattacharya A, Ghosal SK. Transdermal delivery of trazodone hydrochloride from acrylic films prepared from aqueous latex. Indian J Pharm Sci. 2006;68:41–5.
Gupta Sadhana P, Jain SK. Effective and controlled transdermal delivery of Losartan potassium. Indian J Pharm Sci. 2005;67(3):346–50.
Samanta MK, Dube R, Suresh B. Transdermal drug delivery system of haloperidol to overcome self-induced extrapyramidal syndrome. Drug Dev Ind Pharm. 2003;29:405–15.
Zobrist RH, Quan DY, Thomas HM, Stanworth S. Pharmacokinetics and metabolism of transdermal oxybutynin: in vitro and in vivo performance of a novel delivery system. Pharm Res. 2003;20:103.
Shargel L, Andrew BC. Applied biopharmaceutics and pharmacokinetics. 3rd ed. London: Prentice Hall International Inc; 1992. p. 293–312.
Chein YW. Novel drug delivery systems, 2nd revised and expanded edition. New York: Marcel Dekker; 1992. p. 301–75.
Kennedy JF, Bradshaw IJ. Production, properties and applications of Xanthan. Prog Ind Microbiol. 1984;19:319–71.
Sandford PA, Baird J. Production, properties and applications of xanthan gum. In: Aspinall GO, editor. The polysaccharides, vol. 7. Prague: Academia Press; 1983. p. 161–9.
Harding NE, Cleary JM, Telpi L. The polysaccharides. In: Hui YH, Khachatourians GG, editors. Food biotechnology: microorganisms. New York: VCH Publishers Inc; 1995. p. 495. ch.12.
Pelletier E, Viebke C, Meadows J, Williams PA. A rheological study of the order–disorder conformational transition of xanthan gum. Biopolymers. 2001;59:339–46.
Lu MF, Woodward L, Borodkin S. Xanthan gum and alginate based controlled release theophylline formulations. Drug Dev Ind Pharm. 1991;17:1987–2004.
Talukdar MM, Plaizier-Vercammen J. Evaluation of Xanthan gum as a hydrophilic matrix for controlled release dosage form preparations. Drug Dev Ind Pharm. 1993;19:1037–46.
Tobyn MJ, Staniforth JN, Baichwal AR, McCall TW. Prediction of physical properties of a novel polysaccharide controlled release system. Int J Pharm. 1996;128:113–22.
Tonnesen HH, Karlsen J. Alginate in drug delivery systems. Drug Dev Ind Pharm. 2002;28:621–30.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Rajesh, N., Siddaramaiah Feasibility of xanthan gum–sodium alginate as a transdermal drug delivery system for domperidone. J Mater Sci: Mater Med 20, 2085–2089 (2009). https://doi.org/10.1007/s10856-009-3774-5
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10856-009-3774-5