Skip to main content

Advertisement

SpringerLink
Log in

Strontium oxide doped quaternary glasses: effect on structure, degradation and cytocompatibility

  • Published:
Journal of Materials Science: Materials in Medicine Aims and scope Submit manuscript

Abstract

This preliminary study focuses on the effect of adding SrO to a Ti-containing quaternary phosphate glass system denoted by P2O5–Na2O–CaO–TiO2. The following four different glass compositions were manufactured: 0.5P2O5–0.17Na2O–0.03TiO2–(0.3−x)CaO–xSrO where x = 0, 0.01, 0.03 and 0.05. Structural characterisation revealed glass transition temperatures in the range 427–437°C and the presence of sodium calcium phosphate as the dominant phase in all the glasses. Degradation and ion release studies conducted over a 15-day period revealed that the Sr-containing glasses showed significantly higher degradation and ion release rates than the Sr-free glass. Cytocompatibility studies performed over a 7-day period using MG63 cells showed that the addition of 5 mol% SrO yielded glasses with cell viability nearly equivalent to that observed for quaternary TiO2 glasses.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7

Similar content being viewed by others

References

  1. J.C. Knowles, J. Mater. Chem. 13, 2395 (2003). doi:10.1039/b307119g

    Article  CAS  Google Scholar 

  2. K. Franks, V. Salih, J.C. Knowles, J. Mater. Sci.: Mater. Med. 13, 549 (2002). doi:10.1023/A:1015122709576

    Article  CAS  Google Scholar 

  3. X.Y. Yu, D.E. Day, G.J. Long, R.K. Brow, J. Non-Cryst. Solids 215, 21 (1997). doi:10.1016/S0022-3093(97)00022-7

    Article  ADS  CAS  Google Scholar 

  4. C.S. Ray, X. Fang, M. Karabulut, G.K. Marasinghe, D.E. Day, J. Non-Cryst. Solids 249, 1 (1999). doi:10.1016/S0022-3093(99)00304-X

    Article  ADS  CAS  Google Scholar 

  5. I. Ahmed, C.A. Collins, M. Lewis, I. Olsen, J.C. Knowles, Biomaterials 25, 3223 (2004). doi:10.1016/j.biomaterials.2003.10.013

    Article  PubMed  CAS  Google Scholar 

  6. E.A. Abou Neel, I. Ahmed, J.J. Blaker, A. Bismarck, A.R. Boccaccini, M.P. Lewis, S.N. Nazhat, J.C. Knowles, Acta Biomater. 1, 553 (2005). doi:10.1016/j.actbio.2005.05.001

    Article  PubMed  CAS  Google Scholar 

  7. E.A. Abou Neel, I. Ahmed, J. Pratten, S.N. Nazhat, J.C. Knowles, Biomaterials 26, 2247 (2005). doi:10.1016/j.biomaterials.2004.07.024

    Article  CAS  Google Scholar 

  8. R. Shah, A.C.M. Sinanan, J.C. Knowles, N.P. Hunt, M.P. Lewis, Biomaterials 26, 1497 (2005). doi:10.1016/j.biomaterials.2004.04.049

    Article  PubMed  CAS  Google Scholar 

  9. M. Navarro, M.-P. Ginebra, J.A. Planell, J. Biomed. Mater. Res. A 67A, 1009 (2003). doi:10.1002/jbm.a.20014

    Article  CAS  Google Scholar 

  10. V. Rajendran, A.V. Gayathri Devi, M. Azooz, F.H. El-Batal, J. Non-Cryst. Solids 353, 77 (2006). doi:10.1016/j.jnoncrysol.2006.08.047

    Article  ADS  CAS  Google Scholar 

  11. E.A. Abou Neel, T. Mizoguchi, M. Ito, M. Bitar, V. Salih, J.C. Knowles, Biomaterials 28, 2967 (2007). doi:10.1016/j.biomaterials.2007.03.018

    Article  PubMed  CAS  Google Scholar 

  12. E.A. Abou Neel, W. Chrzanowski, J.C. Knowles, Acta Biomater. 4, 523 (2008). doi:10.1016/j.actbio.2007.11.007

    Article  PubMed  CAS  Google Scholar 

  13. E.A. Abou Neel, J.C. Knowles, J. Mater. Sci.: Mater. Med. 19, 377 (2008). doi:10.1007/s10856-007-3079-5

    Article  CAS  Google Scholar 

  14. V. Salih, A. Patel, J.C. Knowles, Biomed. Mater. 2, 11 (2007). doi:10.1088/1748-6041/2/1/003

    Article  PubMed  ADS  CAS  Google Scholar 

  15. E.A. Abou Neel, L.A. O’Dell, M.E. Smith, J.C. Knowles, J. Mater. Sci.: Mater. Med. 19, 1669 (2008). doi:10.1007/s10856-007-3313-1

    Article  CAS  Google Scholar 

  16. I. Ahmed, E.A. Abou Neel, S.P. Valappil, S.N. Nazhat, D.M. Pickup, D. Carta, D.L. Carroll, R.J. Newport, M.E. Smith, J.C. Knowles, J. Mater. Sci. 42, 9827 (2007). doi:10.1007/s10853-007-2008-9

    Article  ADS  CAS  Google Scholar 

  17. S.P. Valappil, D.M. Pickup, D.L. Carroll, C.K. Hope, J. Pratten, R.J. Newport, M.E. Smith, M. Wilson, J.C. Knowles, Antimicrob. Agents Chemother. 51, 4453 (2007). doi:10.1128/AAC.00605-07

    Article  PubMed  CAS  Google Scholar 

  18. S.P. Valappil, J.C. Knowles, M. Wilson, Appl. Environ. Microbiol. 74, 5228 (2008). doi:10.1128/AEM.00086-08

    Article  PubMed  CAS  Google Scholar 

  19. S.P. Valappil, D. Ready, E.A. Abou Neel, D.M. Pickup, W. Chrzanowski, L.A. O’Dell, R.J. Newport, M.E. Smith, M. Wilson, J.C. Knowles, Adv. Funct. Mater. 18, 732 (2008). doi:10.1002/adfm.200700931

    Article  CAS  Google Scholar 

  20. A. Guida, M.R. Towler, J.G. Wall, R.G. Hill, S. Eramo, J. Mater. Sci. Lett. 22, 1401 (2003). doi:10.1023/A:1025794927195

    Article  CAS  Google Scholar 

  21. P.J. Marie, Osteoporos. Int. 14, S9 (2003)

    PubMed  CAS  Google Scholar 

  22. A. Barbara, P. Delannoy, B.G. Denis, P.J. Marie, Metabolism 53, 532 (2004). doi:10.1016/j.metabol.2003.10.022

    Article  PubMed  CAS  Google Scholar 

  23. P.J. Marie, Bone 40, S5 (2007). doi:10.1016/j.bone.2007.02.003

    Article  CAS  Google Scholar 

  24. C. Wu, Y. Ramaswamy, D. Kwik, H. Zreiqat, Biomaterials 28, 3171 (2007). doi:10.1016/j.biomaterials.2007.04.002

    Article  PubMed  CAS  Google Scholar 

  25. J. Lao, E. Jallot, J.M. Nedelec, Chem. Mater. 20, 4969 (2008). doi:10.1021/cm800993s

    Article  CAS  Google Scholar 

  26. M. Towler, D. Boyd, C. Freeman, I.M. Brook, P. Farthing, J. Biomater. Appl. (2008). doi:10.1177/0885328208094306

  27. E.A. Abou Neel, W. Chrzanowski, D.M. Pickup, L.A. O’Dell, N.J. Mordan, R.J. Newport, M.E. Smith, J.C. Knowles, J. R. Soc. Interface (2008). doi:10.1098/rsif.2008.0348

  28. Q.Z. Chen, A. Efthymiou, V. Salih, A.R. Boccaccini, J. Biomed. Mater. Res. A 84A, 1049 (2008). doi:10.1002/jbm.a.31512

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Biomaterials and Tissue Engineering, Eastman Dental Institute, University College London, 256 Gray’s Inn Road, London, WC1X 8LD, UK

    N. J. Lakhkar, E. A. Abou Neel, V. Salih & J. C. Knowles

Authors
  1. N. J. Lakhkar
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. E. A. Abou Neel
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. V. Salih
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. J. C. Knowles
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to J. C. Knowles.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Lakhkar, N.J., Abou Neel, E.A., Salih, V. et al. Strontium oxide doped quaternary glasses: effect on structure, degradation and cytocompatibility. J Mater Sci: Mater Med 20, 1339–1346 (2009). https://doi.org/10.1007/s10856-008-3688-7

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10856-008-3688-7

Keywords

Search

Navigation